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首页> 外文期刊>Rheumatology >Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis
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Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis

机译：Vigna angularis抑制IL-6诱导的细胞信号转导并改善胶原蛋白诱导的关节炎

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Objectives: The present study was conducted in order to assess whether extracts or isolated compounds from Vigna angularis were able to suppress IL-6 signalling and to show the therapeutic effect on collageninduced arthritis (CIA) in mice. Methods: The effect of V. angularis on IL-6 signalling was studied by measuring Stat3-dependent luciferase activity, expression of inflammation-related genes, and phosphorylation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase (ERK) induced by IL-6. CIA was induced by immunizing with bovine type II collagen. V. angularis extract (VAE) was administrated orally at 50 and 100 mg/kg from day 1 to day 28. Induction of arthritis was evaluated with a visual scoring system and histological analysis. Results: Extracts or two triterpenoid compounds from V. angularis showed potent inhibitory effects on pSTAT3-inducible luciferase activity, STAT3 tyrosine phosphorylation and the expression of inflammationrelated genes induced by IL-6. Administration of VAE significantly suppressed the progression of CIA, accompanied by a reduced antibody response to type II collagen and protection from tissue damage in knee joints. Conclusion: Administration of VAE has a therapeutic effect on CIA and this effect is associated with the inhibitory activity on IL-6/STAT3 signalling. These results suggest that extracts or compounds from V. angularis could be a useful treatment for diseases related to IL-6, including RA.
机译：目的：进行本研究是为了评估Vigna angularis的提取物或分离出的化合物是否能够抑制IL-6信号传导，并显示对小鼠胶原性关节炎（CIA）的治疗作用。方法：通过测量Stat3依赖性荧光素酶活性，炎症相关基因的表达以及Janus激酶2（JAK2），信号转导子和转录激活子3（STAT3）的磷酸化来研究角果弧菌对IL-6信号的影响。和IL-6诱导的细胞外信号调节激酶（ERK）。通过用牛II型胶原免疫来诱导CIA。从第1天到第28天，以50和100mg / kg口服施用角果提取物（VAE）。通过视觉评分系统和组织学分析评价关节炎的诱导。结果：角果弧菌的提取物或两种三萜类化合物对pSTAT3诱导的荧光素酶活性，STAT3酪氨酸磷酸化和IL-6诱导的炎症相关基因的表达具有有效的抑制作用。施用VAE可以显着抑制CIA的进展，同时降低对II型胶原的抗体反应，并保护膝关节免受组织损伤。结论：VAE的给药对CIA具有治疗作用，并且该作用与对IL-6 / STAT3信号传导的抑制活性有关。这些结果表明，来自角豆的提取物或化合物可能是与IL-6相关的疾病（包括RA）的有用治疗方法。

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