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首页> 外文期刊>Rheumatology >Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis.
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Markedly increased IL-18 liver expression in adult-onset Still's disease-related hepatitis.

机译：在成年的斯蒂尔氏病相关肝炎中，IL-18肝表达显着增加。

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OBJECTIVES: First, to investigate the prevalence of liver involvement in adult-onset Still's disease (AOSD) Italian patients; secondly, to measure serum IL-18 concentration and correlate its level to other inflammatory markers and disease activity; and thirdly to characterize the expression level and the cellular source of IL-18 in the liver of a patient with AOSD with hepatitis. METHODS: The clinical charts of 41 consecutive Italian AOSD patients were evaluated with special attention to liver involvement. Serum levels of IL-18 were measured in 21 patients. Finally, the case of a 33-year-old woman with hepatitis where a liver biopsy was obtained and sections stained with antibodies against IL-18 and CD68 is described in detail. RESULTS: Of the 41 AOSD patients, 32 and 39% displayed increased AST level or ALT level, respectively, generally normalizing with steroid treatment, while 41% had evidence of hepatosplenomegaly. Circulating IL-18 levels were significantly higher in those with active disease compared with 85 controls. A correlation was observed between IL-18 serum level and disease activity, serum ferritin level and neutrophil count. IL-18 concentration was markedly increased in the patient with active hepatitis. Intense IL-18 expression was detected within the liver parenchyma and double staining with IL-18 and CD68 clearly showed colocalization of the cytokine with the macrophage marker. CONCLUSION: Macrophage-derived IL-18 might play a central role in the pathogenesis of AOSD. IL-18 serum level is higher in patients with active AOSD and its local, rather than systemic, expression may be responsible for tissue damage in some target organs, such as liver.
机译：目的：首先，调查成年意大利斯蒂尔氏病（AOSD）患者的肝脏受累情况。其次，测量血清IL-18的浓度并将其水平与其他炎症标志物和疾病活性相关联;第三，表征患有AOSD的肝炎患者的肝脏中IL-18的表达水平和细胞来源。方法：对41例连续的意大利AOSD患者的临床图表进行了评估，并特别注意肝脏受累情况。测定了21名患者的血清IL-18水平。最后，详细描述了一名33岁的肝炎女性患者，该患者获得了肝活检并被抗IL-18和CD68抗体染色的切片。结果：在41例AOSD患者中，分别有32％和39％的患者显示AST水平或ALT水平升高，一般用类固醇治疗即可恢复正常，而41％的患者有肝脾肿大的迹象。患有活动性疾病的人的循环IL-18水平明显高于85个对照组。在IL-18血清水平和疾病活性，血清铁蛋白水平和中性粒细胞计数之间观察到相关性。活动性肝炎患者的IL-18浓度明显升高。在肝实质内检测到强烈的IL-18表达，用IL-18和CD68双重染色清楚地显示了细胞因子与巨噬细胞标记物的共定位。结论：巨噬细胞源性IL-18可能在AOSD的发病过程中发挥重要作用。具有活跃AOSD的患者中IL-18血清水平较高，其局部而非全身表达可能是某些目标器官（例如肝脏）组织受损的原因。

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