...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Rheumatology >Pulmonary hypertension in systemic lupus erythematosus: Echocardiography-based definitions predict 6-year survival
【24h】

Pulmonary hypertension in systemic lupus erythematosus: Echocardiography-based definitions predict 6-year survival

机译：系统性红斑狼疮的肺动脉高压：基于超声心动图的定义可预测6年生存率

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: The aim of this study was to investigate whether a core of echocardiography-based definitions of pulmonary hypertension (PH), as proposed by the European Society of Cardiology, European Respiratory Society and International Society of Heart and Lung Transplantation (ESC/ERS/ISHLT), may predict long-term survival in patients with SLE. Methods: A post hoc analysis from a cohort of SLE patients followed over 6 years was performed. Clinical associations, serum biomarkers, autoantibody profile, length of survival and all-cause mortality were assessed. Results: Out of 115 patients from the original cohort, 55 satisfied our inclusion criteria and were grouped according to echocardiography as unlikely (n = 26), possible (n = 16) or likely (n = 13) to have PH. Likely PH was associated with a history of pulmonary thromboembolism, higher cumulated organ damage and active arthritis. The 6-year survival rate was 88% in the unlikely PH group, 87% in the possible PH group and 68% in the likely PH group (P<0.05). Serum levels of endothelin-1, monocyte chemotactic protein-1, IL-17, and IFN-γ as well as a number of autoantibodies were no different between groups. Conclusion: The ESC/ERS/ISHLT echocardiography-based definitions of PH are useful to predict 6-year mortality in SLE patients. A history of pulmonary thromboembolism and lung vasculitis/haemorrhage, cumulated organ damage and long-lasting disease are associated with PH in SLE.
机译：目的：本研究的目的是调查是否由欧洲心脏学会，欧洲呼吸学会和国际心肺移植学会（ESC / ERS ​​/）提出的基于超声心动图的肺动脉高压（PH）定义的核心ISHLT），可以预测SLE患者的长期生存。方法：对6年以上的SLE患者进行事后分析。评估临床关联，血清生物标志物，自身抗体谱，生存时间和全因死亡率。结果：在最初队列的115名患者中，有55名满足我们的纳入标准，并根据超声心动图将其分为可能性（n = 26），可能（n = 16）或可能性（n = 13）。 PH可能与肺血栓栓塞，更严重的器官损伤和活动性关节炎病史有关。不太可能的PH组的6年生存率为88％，可能的PH组为87％，可能的PH组为68％（P <0.05）。两组之间的血清内皮素-1，单核细胞趋化蛋白-1，IL-17和IFN-γ以及多种自身抗体水平无差异。结论：基于ESC / ERS ​​/ ISHLT超声心动图的PH定义可用于预测SLE患者的6年死亡率。 SLE的PH与肺血栓栓塞和肺血管炎/出血史，器官累积损伤和长期疾病史相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号