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首页> 外文期刊>RSC Advances >Highly promising discrimination of various catecholamines using ratiometric fluorescence probes with intermolecular self-association of two sensing elements
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Highly promising discrimination of various catecholamines using ratiometric fluorescence probes with intermolecular self-association of two sensing elements

机译：使用比例荧光探针和两个传感元件的分子间自缔合，对各种儿茶酚胺的鉴别很有前途

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摘要

Two sensing elements based on fluorescence probes have been employed as the promising discriminating sensors of two catecholamines, dopamine (DA) and norepinephrine (NE), acting as a proper guest linker between two self-recognition sensing components. Surprisingly, in the presence of epinephrine (EPI), sensor NB containing boronic acid connected to a napthalimide unit demonstrated a very strong fluorescence enhancement while a large fluorescence quenching was observed in the case of DA and NE. To differentiate the structural similarity of DA and NE, an appropriately designed small fluorescence sensor CC containing a crown-ether attached to coumarin showed complementary recognition to an ammonium ion based catecholamine. The combination of NB and CC is capable of the differentiation of DA and NE with dual emission bands under a PET mechanism. The dual emission ratio (I-475/I-384) of the NB-DA-CC complex showed different values from those of the NB-NE-CC complex. Additionally, the PCA analysis using mixed sensors of NB and CC obviously separated DA and NE better than a single sensing element. This systematic approach is the first report showing a high potential for the identification of DA and NE using ratiometric fluorescence sensors with dual emission by two sensing elements.
机译：基于荧光探针的两个传感元件已被用作两种儿茶酚胺（多巴胺（DA）和去甲肾上腺素（NE））的有希望的区分传感器，它们充当两个自我识别传感组件之间的适当客体连接物。出乎意料的是，在肾上腺素（EPI）的存在下，含有连接到萘甲酰亚胺单元的硼酸的传感器NB表现出非常强的荧光增强作用，而在DA和NE的情况下观察到了大的荧光猝灭作用。为了区分DA和NE的结构相似性，经过适当设计的包含连接到香豆素的冠醚的小型荧光传感器CC显示出对基于铵离子的儿茶酚胺的互补识别。 NB和CC的结合能够在PET机制下区分具有双发射带的DA和NE。 NB-DA-CC配合物的双重发射比（I-475 / I-384）显示出与NB-NE-CC配合物的双重发射率不同的值。此外，使用NB和CC混合传感器进行的PCA分析明显比单个传感元件更好地分离了DA和NE。这种系统的方法是第一个报告，显示了使用比例荧光传感器通过两个传感元件双重发射来鉴定DA和NE的巨大潜力。

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