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A multicentre study on the reliability of qualitative and quantitative nail-fold videocapillaroscopy assessment

机译：定性和定量指甲折叠式电毛细管镜评估可靠性的多中心研究

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Objective: To investigate the inter- and intra-observer reliability of both qualitative and quantitative parameters used in the assessment of nail-fold capillaroscopy images. Methods: Fifty mosaic nail-fold images of healthy controls (n = 10), patients with primary RP (n = 10) and SSc (n = 30) were assessed in random order by two blinded observers on two occasions at centres in Sweden, UK and The Netherlands. Each image was therefore scored by six observers twice. Results: Inter- and intra-observer reliability of quantitative parameters showed substantial to almost perfect agreement [inter- and intra-observer weighted κ's for the number of widened capillaries was 0.75 and 0.87 and giant capillaries was 0.84 and 0.92, intra-class correlation coefficients (ICCs) for capillary density was 0.87 and 0.92 and total loop width was 0.94 and 0.98, respectively]. Qualitative parameters including architecture, avascularity, haemorrhage, crossed, ramified and bushy capillaries showed moderate to substantial inter-observer reproducibility (weighted κ ranging from 0.47 to 0.73), and substantial intra-observer repeatability (weighted κ ranging from 0.71 to 0.80), whereas the scoring of tortuous and bizarre capillaries showed poor inter-observer and substantial intra-observer agreement (inter-observer weighted κ's was 0.39 and 0.21 and intra-observer weighted κ's was 0.68 and 0.76, respectively). Conclusion: All quantitative and certain qualitative parameters are highly reliable in terms of inter- and intra-observer agreement. A combination of parameters with the highest reliability should be incorporated into future capillaroscopic scoring systems in studies of prediction and monitoring of SSc spectrum disorders.
机译：目的：探讨观察者间和观察者内用于评估倍褶毛细血管镜图像的定性和定量参数的可靠性。方法：在瑞典的医疗中心，由两名盲人分别随机两次评估了健康对照（n = 10），原发性RP（n = 10）和SSc（n = 30）患者的五十张镶嵌指甲折叠图像，英国和荷兰。因此，每个图像由六位观察员评分两次。结果：观察者间和观察者间定量参数的可靠性显示出基本至几乎完美的一致[类别间相关系数，观察者间和观察者间加权κ为加宽的毛细血管数量分别为0.75和0.87和巨毛细管为0.84和0.92 （ICC）的毛细管密度分别为0.87和0.92，总环宽分别为0.94和0.98]。定性参数，包括结构，无血管性，出血，交叉，分叉和浓密的毛细血管，显示观察者之间具有中等到较高的重现性（加权κ范围从0.47至0.73），以及观察者内部的重现性（加权κ范围从0.71至0.80），曲折和奇异毛细血管的评分显示观察者之间的观察力差和观察者内部的一致性（观察者之间加权的κ分别为0.39和0.21，观察者内部加权的κ分别为0.68和0.76）。结论：就观察者之间和观察者之间的一致而言，所有定量和定性参数都是高度可靠的。在预测和监测SSc频谱疾病时，应将具有最高可靠性的参数组合纳入未来的毛细管镜评分系统中。

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