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Magnetically separable Fe3O4-SO3H nanoparticles as an efficient solid acid support for the facile synthesis of two types of spiroindole fused dihydropyridine derivatives under solvent free conditions

机译:磁性可分离的Fe3O4-SO3H纳米颗粒作为有效的固体酸载体,可在无溶剂条件下轻松合成两种类型的螺并吲哚并稠合的二氢吡啶衍生物

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摘要

Magnetically separable Fe3O4-SO3H nanoparticles are found to act as an efficient solid supported acid catalyst for the facile synthesis of two types of spiroindole fused dihydropyridine derivatives such as spiro[indolo-3,10'-indeno[1,2-b]quinolin]-2,4,11'-triones and indenoquinoline-spirooxindoles under solvent-free conditions. Depending upon the nature of N-substitutions of the starting isatins (N-H or N-R/Ar) two different types of products are formed through three component one-pot condensation reactions. Operational simplicity, reduced reaction time, lower reaction temperature, elimination of solvents, high yields of the products, easy separation of Fe3O4-SO3H nanoparticles by means of an external magnetic bar and recyclability of Fe3O4-SO3H nanoparticles make the present method economical, green and sustainable.
机译:发现磁性可分离的Fe3O4-SO3H纳米粒子可作为一种有效的固体负载酸催化剂,用于轻松合成两种类型的螺吲哚并稠的二氢吡啶衍生物,例如螺[indolo-3,10'-茚并[1,2-b]喹啉] -2,4,11'-三酮和茚并喹啉-spirooxindoles在无溶剂条件下。取决于起始异构素(N-H或N-R / Ar)的N取代的性质,通过三组分一锅缩合反应可形成两种不同类型的产物。操作简便,减少反应时间,降低反应温度,消除溶剂,产物收率高,易于通过外部磁棒分离Fe3O4-SO3H纳米颗粒以及Fe3O4-SO3H纳米颗粒的可回收性使本方法经济,绿色,环保可持续的。

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