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首页> 外文期刊>RSC Advances >Protein-resistance performance of amphiphilic copolymer brushes consisting of fluorinated polymers and polyacrylamide grafted from silicon surfaces
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Protein-resistance performance of amphiphilic copolymer brushes consisting of fluorinated polymers and polyacrylamide grafted from silicon surfaces

机译：由硅表面接枝的含氟聚合物和聚丙烯酰胺组成的两亲共聚物刷的抗蛋白质性能

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摘要

A series of random copolymer brushes of acrylamide (AM) and 2-(perfluorinated hexyl)ethyl methacrylate (FMA) were grafted from initiator-functionalized silicon wafers by surface-initiated atom transfer radical polymerization. The water contact angle, X-ray photoelectron spectroscopy and atomic force microscopy were used to characterize surface wettability, surface composition, and morphology of the surfaces modified with polymer brushes, respectively. The protein-resistance performance of the surfaces grafted with polymer brushes was evaluated using micro-BCA protein assay reagent. It was found that the random copolymer brushes with the optimal ratio of AM to FMA in monomers showed the best protein-resistance performance, however, the optimal ratio is different for resisting bovine serum albumin and human plasma fibrinogen adsorption. For resisting bovine serum albumin adsorption, the optimal ratio of AM to FMA in monomers is 1 : 3, while the optimal is 3 : 1 for human plasma fibrinogen adsorption resistance. The results provide further evidence that surface compositional heterogeneities and microphase segregation of fluorinated moieties of amphiphilic random copolymer brushes significantly impact protein adsorption behaviors.
机译：通过表面引发的原子转移自由基聚合，从引发剂官能化的硅片上接枝了一系列丙烯酰胺（AM）和甲基丙烯酸2-（全氟己基）乙酯（FMA）的无规共聚物刷。使用水接触角，X射线光电子能谱和原子力显微镜分别表征了用聚合物刷改性的表面的润湿性，表面组成和形态。使用micro-BCA蛋白质测定试剂评估了用聚合物刷移植的表面的蛋白质抗性性能。结果表明，单体中AM与FMA的最佳比例的无规共聚物刷表现出最佳的蛋白质抗性性能，但是，该最佳比例在抵抗牛血清白蛋白和人血浆纤维蛋白原吸附方面却有所不同。为了抵抗牛血清白蛋白的吸附，单体中AM与FMA的最佳比例为1：3，而对人血浆纤维蛋白原的吸附阻力为3：1。结果提供了进一步的证据，表明两亲无规共聚物刷的氟化部分的表面组成不均一性和微相偏析显着影响了蛋白质的吸附行为。

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