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首页> 外文期刊>RSC Advances >Cyclodextrin mediated polymer coupling via thiol-maleimide conjugation: facile access to functionalizable hydrogels
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Cyclodextrin mediated polymer coupling via thiol-maleimide conjugation: facile access to functionalizable hydrogels

机译：环糊精介导的通过硫醇-马来酰亚胺偶联的聚合物偶联：容易获得功能化水凝胶

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摘要

Fabrication of well-defined chemically cross-linked poly(ethylene glycol) (PEG)-based hydrogels using the thiol-maleimide addition reaction is reported. Maleimide containing homobifunctional PEGs with different molecular weights were synthesized and reacted with thiol functionalized beta-cyclodextrin (beta-CD(SH)(7)) to yield hydrogels with high efficiency under mild conditions. The resulting hydrogels were characterized by their water uptake properties, surface morphologies and rheological behaviours. In order to introduce reactive functional groups into the hydrogels, the stoichiometry of the thiol and maleimide groups was varied to obtain either thiol or maleimide functionalized hydrogels. Efficient functionalization of these reactive hydrogels in a tailored fashion was demonstrated through conjugation of appropriately functionalized fluorescent dye molecules.
机译：报道了使用硫醇-马来酰亚胺加成反应制备明确定义的化学交联的基于聚乙二醇（PEG）的水凝胶。合成了含有不同分子量的同双功能PEG的马来酰亚胺，并使其与巯基官能化的β-环糊精（β-CD（SH）（7））反应，在温和条件下高效制备了水凝胶。所得水凝胶的特征在于其吸水性能，表面形态和流变行为。为了将反应性官能团引入水凝胶，改变硫醇和马来酰亚胺基团的化学计量以获得硫醇或马来酰亚胺官能化的水凝胶。通过适当功能化的荧光染料分子的缀合，证明了这些反应性水凝胶以定制方式进行的有效功能化。

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