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首页> 外文期刊>RSC Advances >Synthesis and optical properties of emission-tunable PbS/CdS core-shell quantum dots for in vivo fluorescence imaging in the second near-infrared window
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Synthesis and optical properties of emission-tunable PbS/CdS core-shell quantum dots for in vivo fluorescence imaging in the second near-infrared window

机译：发射可调PbS / CdS核-壳量子点的合成和光学性质，用于第二近红外窗口中的体内荧光成像

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摘要

Near-infrared (NIR) fluorescence imaging at wavelengths from 1000 to 1500 nm (2nd-NIR window) is a promising modality for in vivo fluorescence imaging because of the deeper tissue penetration with lower tissue scattering of the 2nd-NIR light. For such in vivo fluorescence imaging, highly fluorescent probes in the 2nd-NIR wavelength region are needed. Although single-walled carbon nanotubes and Ag2S quantum dots (QDs) have recently appeared as 2nd-NIR fluorescent probes, their fluorescence brightness is relatively low (quantum yields <6%). In this study, we developed a synthetic method for preparing highly fluorescent PbS/CdS core-shell QDs (quantum yields, 17% in water) with narrow band widths (<200 nm) that emit in the 2nd-NIR region. By overcoating of a CdS shell onto a PbS QD core, we could easily control the emission wavelengths of the PbS/CdS QDs at 1000 to 1500 nm. To use the QDs for in vivo imaging, we investigated the optical properties of QDs (penetration depth and blurring of fluorescence images in slices of skin, brain, and heart in mice) in the 2nd-NIR region. We found that the 2nd-NIR fluorescence imaging at ca.1300 nm using the PbS/CdS QDs results in the highest signal to background ratio with a low blurring for in vivo imaging. To confirm the capabilities of the PbS/CdS QDs for in vivo imaging, we conducted fluorescence angiography imaging of a mouse head.
机译：波长为1000至1500 nm的近红外（NIR）荧光成像（第2个NIR窗口）是一种有前途的体内荧光成像方法，因为第2个NIR光的组织穿透更深，组织散射更小。对于这种体内荧光成像，需要第二近红外波长区域的高荧光探针。尽管单壁碳纳米管和Ag2S量子点（QD）最近已作为第二近红外荧光探针出现，但它们的荧光亮度相对较低（量子产率<6％）。在这项研究中，我们开发了一种合成方法，用于制备在第二NIR区域发射的窄带宽（<200 nm）的高荧光PbS / CdS核-壳QD（量子产率，在水中为17％）。通过在CbS QD核上覆盖CdS外壳，我们可以轻松地将PbS / CdS QD的发射波长控制在1000至1500 nm。为了将量子点用于体内成像，我们研究了第二近红外区域的量子点的光学特性（穿透深度和小鼠皮肤，大脑和心脏切片中荧光图像的模糊）。我们发现使用PbS / CdS QD在约1300 nm处进行第二次近红外荧光成像可得到最高的信噪比，而对体内成像的模糊性却很低。为了确认PbS / CdS QD在体内成像的功能，我们对小鼠头部进行了荧光血管造影成像。

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