Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties

Yang Zhang-You; Luo Sheng-Lin; Li Hong; Dong Shi-Wu; He Jian; Jiang Hong; Li Rong; Yang Xiao-Chao

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Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties

机译：阿仑膦酸酯作为二氧化铈纳米颗粒表面涂层的牢固锚定剂：易于结合并改善了生物学特性

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The bisphosphonate group of alendronate was found to possess high binding affinity to ceria nanoparticles (CNPs). Using alendronate as an anchor, functional molecules could be easily grafted onto CNPs leading to enhanced enzyme mimetic activity, reduced cytotoxicity, improved stability, prolonged blood circulation, and decreased liver and especially spleen accumulation of the nanoparticles.

机译：发现阿仑膦酸盐的双膦酸酯基团对二氧化铈纳米颗粒（CNP）具有高结合亲和力。使用阿仑膦酸盐作为锚定物，可以将功能分子轻松移植到CNP上，从而提高酶模拟活性，降低细胞毒性，改善稳定性，延长血液循环以及减少肝脏，尤其是纳米颗粒的脾脏积聚。

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《RSC Advances》 |2014年第104期|共5页
作者
Yang Zhang-You; Luo Sheng-Lin; Li Hong; Dong Shi-Wu; He Jian; Jiang Hong; Li Rong; Yang Xiao-Chao;
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1. Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties [J] . Yang Zhang-You, Luo Sheng-Lin, Li Hong, RSC Advances . 2014,第104期

机译：阿仑膦酸酯作为二氧化铈纳米颗粒表面涂层的牢固锚定剂：易于结合并改善了生物学特性
2. Preparation and properties of fluoroalkyl end-capped vinyltrimethoxysilane oligomeric nanoparticles-A new approach to facile creation of a completely superhydrophobic coating surface with these nanoparticles [J] . Hideo Sawada, Toshihiro Suzuki, Hiroki Takashima Colloid and polymer science . 2008,第13期

机译：氟代烷基封端的乙烯基三甲氧基硅烷低聚纳米粒子的制备和性能-用这些纳米粒子轻松创建完全超疏水涂层表面的新方法
3. Preparation and properties of fluoroalkyl end-capped vinyltrimethoxysilane oligomeric nanoparticles—A new approach to facile creation of a completely superhydrophobic coating surface with these nanoparticles [J] . Hideo Sawada, Toshihiro Suzuki, Hiroki Takashima, Colloid and Polymer Science . 2008,第13期

机译：氟代烷基封端的乙烯基三甲氧基硅烷低聚纳米粒子的制备和性能-利用这些纳米粒子轻松创建完全超疏水涂层表面的新方法
4. Facile synthesis of beaded ceria nanoparticles along carbon nanotubes [C] . CHEN Xiaolong, rnWANG Jiali, rnLi Xin The 6th China international conference on nanoscience and technology . 2007

机译：沿着碳纳米管轻松合成珠状二氧化铈纳米颗粒
5. Study of ceria nanoparticles synthesis and the performance of nano-ceria coating for high temperature oxidation resistance in combustion atmosphere [D] . Mao, Lingke. 2016

机译：燃烧大气中高温氧化耐氧化铝涂层合成及纳米纤维涂层的性能研究
6. Alendronate‐anchored PEGylation of ceria nanoparticles promotes human hepatoma cell proliferation via AKT/ERK signaling pathways [O] . Heng Cheng, Zhong‐Li Liao, Lin‐Hong Ning, 2017

机译：氧化铈纳米颗粒的阿仑膦酸盐固定的PEG化可通过AKT / ERK信号通路促进人肝癌细胞的增殖
7. Alendronate-anchored PEGylation of ceria nanoparticles promotes human hepatoma cell proliferation via AKT/ERK signaling pathways [O] . Heng Cheng, Zhong-Li Liao, Lin-Hong Ning, 2017

机译：Ceria纳米粒子的Alendronate-锚定PEG化通过AKT / ERK信号通路促进人肝癌细胞增殖

Alendronate as a robust anchor for ceria nanoparticle surface coating: facile binding and improved biological properties

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