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首页> 外文期刊>Rheumatology >Body weight at early and middle adulthood, weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis
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Body weight at early and middle adulthood, weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis

机译：成年早期和中期的体重，成年早期的体重增加和持续超重是骨关节炎全膝关节和髋关节置换风险的预测指标

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Objectives: To examine the relationships between weight at early and middle adulthood and adult weight gain and the risk of total knee and hip replacement for OA. Methods: At baseline interview during 1990-94, 38 149 participants [mean age 54.9 (S.D. 8.6) years] of the Melbourne Collaborative Cohort Study were asked to recall their weight at age 18-21 years and had their middle age height and weight measured. Total knee and hip replacement for OA between 2001 and 2009 was determined by linking the cohort records to the Australian Orthopaedic Association National Joint Replacement Registry. Results: Greater weight and BMI at age 18-21 years and middle age, weight gain and persistent overweight during this time were associated with an increased risk of total knee and hip replacement. Middle age weight [hazard ratio (HR) per 5 kg 1.25 (95% CI 1.23, 1.27) for knee vs 1.11 (1.09, 1.14) for hip] and BMI [HR per 5 kg/m2 1.80 (1.72, 1.89) vs 1.29 (1.21, 1.37)] and adult weight gain [HR per 5 kg 1.25 (1.23, 1.28) vs 1.10 (1.07, 1.13)] were more strongly associated with the risk of total knee replacement than total hip replacement (P for heterogeneity of HRs <0.0001). Conclusion: Greater body weight and BMI at early and middle adulthood, weight gain and persistent overweight from early to middle adulthood are risk factors for knee and hip OA. Adult weight gain confers stronger risk on knee OA than hip OA. Weight control from early adulthood and avoiding weight gain are important for the prevention of OA.
机译：目的：探讨成年早期和中期的体重与成人体重增加之间的关系，以及全膝关节和髋关节置换骨关节炎的风险。方法：在1990-94年进行的基线访谈中，要求墨尔本合作队列研究的38149名参与者[平均年龄54.9（SD 8.6）岁]回忆他们在18-21岁时的体重，并测量他们的中年身高和体重。通过将队列记录与澳大利亚骨科协会全国关节置换注册中心相关联，可以确定2001年至2009年间OA的膝关节和髋关节置换术总量。结果：18-21岁和中年时期体重和BMI升高，体重增加和持续超重与全膝关节和髋关节置换的风险增加相关。中年体重[膝关节每5公斤的危险比（HR）1.25（95％CI 1.23，1.27）膝关节1.11（1.09，1.14）髋部]和BMI [每5千克/平方米的HR 1.80（1.72，1.89）vs 1.29 （1.21，1.37）]和成人体重增加[每5公斤HR 1.25（1.23，1.28）对1.10（1.07，1.13）]与全髋关节置换的风险比全髋关节置换的风险更密切相关（HR异质性P <0.0001）。结论：成年早期和中期成年体重增加和BMI升高，成年早期到中期成年体重增加和持续超重是膝盖和髋骨OA的危险因素。成人体重增加使膝骨关节炎的风险高于髋骨关节炎。从成年初期开始控制体重并避免体重增加对于预防OA很重要。

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