Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations

Suyan P.; Kumar S. Nishanth; Madhavan Nimisha; Kumar B. S. Dileep; Nair Balagopal N.; Mohamed A. Peer; Warrier K. G. K.; Hareesh U. S.

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Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations

机译：活性氧（ROS）介导的抑制浓度低的ZnS-ZnO纳米复合材料的抗候选活性增强

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Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS-ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution.

机译：通过简单的沉淀技术制备的ZnS-ZnO纳米复合材料显示出对酵母菌白色念珠菌，热带念珠菌和酿酒酵母的增强的抗真菌活性。在室内光的存在下，抗真菌活性明显高于在黑暗条件下，并且明确证实了光催化纳米复合材料在现场产生的活性氧（ROS）的抑制作用。流式细胞仪结果和膜通透性研究进一步证明了ROS的产生。时间杀灭试验和生长曲线分析表明在黑暗条件下抗真菌活性减弱，这主要归因于溶液中的Zn2 +外排。

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《RSC Advances》 |2015年第94期|共11页
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Suyan P.; Kumar S. Nishanth; Madhavan Nimisha; Kumar B. S. Dileep; Nair Balagopal N.; Mohamed A. Peer; Warrier K. G. K.; Hareesh U. S.;
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1. Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations [J] . Suyan P., Kumar S. Nishanth, Madhavan Nimisha, RSC Advances . 2015,第94期

机译：活性氧（ROS）介导的抑制浓度低的ZnS-ZnO纳米复合材料的抗候选活性增强
2. Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells [J] . HucL., LemariéA., GuéraudF., Toxicology in vitro: an international journal published in association with BIBRA . 2012,第5期

机译：低浓度的双酚A诱导HepG2细胞线粒体中活性氧的产生介导的脂质蓄积
3. High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species [J] . Wei Chen, Ying Cai Lin, Xian Yong Ma, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2014,第Null期

机译：高浓度的染料木黄酮通过涉及5-脂氧合酶介导的活性氧生成的机制，在原代肌肉细胞中表现出促氧化作用
4. REACTIVITY OF ACTIVE OXYGEN SPECIES TOWARD C-2 POSITION OF CARBOHYDRATE AND ITS DEPENDENCE ON THE ORIGIN OF ACTIVE OXYGEN SPECIES UNDER OXYGEN BLEACHING CONDITIONS [C] . Akihiko Nakagawa, Tomoya Yokoyama, Yuji Matsumoto ISWFPC;International symposium on wood, fiber and pulping chemistry . 2011

机译：氧漂白条件下活性氧物种对C-2碳酸盐的反应性及其与活性氧物种起源的关系
5. The production of mitochondrial reactive oxygen species at steady-state oxygen concentrations: Implications for oxygen sensing [D] . Hoffman, David Leland, III 2009

机译：稳态氧浓度下线粒体活性氧的产生：对氧传感的意义
6. UVA Radiation Enhances Lomefloxacin-Mediated Cytotoxic Growth-Inhibitory and Pro-Apoptotic Effect in Human Melanoma Cells through Excessive Reactive Oxygen Species Generation [O] . Artur Beberok, Zuzanna Rzepka, Jakub Rok, 2020

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7. Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS–ZnO nanocomposites with low inhibitory concentrations [O] . P. Suyana, S. Nishanth Kumar, Nimisha Madhavan, 2015

机译：反应性氧物种（ROS）介导的ZnS-ZnO纳米复合材料的增强抗鉴定活性，具有低抑制浓度

Reactive oxygen species (ROS) mediated enhanced anti-candidal activity of ZnS-ZnO nanocomposites with low inhibitory concentrations

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