Facile synthesis of pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones by a Ti-grafted polyamidoamine dendritic silica hybrid catalyst via a dual activation route

Sinija P. S.; Sreekumar K.

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Facile synthesis of pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones by a Ti-grafted polyamidoamine dendritic silica hybrid catalyst via a dual activation route

机译：钛接枝的聚酰胺胺树枝状二氧化硅杂化催化剂通过双活化途径轻松合成吡喃并吡唑和3,4-二氢嘧啶-2（1H）-酮

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A simple, highly efficient and ecofriendly approach for the preparation of biologically potent pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones are described here. A Ti-grafted polyamidoamine dendritic silica hybrid catalyst was successfully synthesized, and its catalytic performance was studied in two important multicomponent reactions such as Biginelli reaction and pyranopyrazole synthesis. Studies demonstrate that the crystalline pore wall structure of the dendritic silica hybrid catalyst makes adsorption of reactants easy. Combining the Lewis acidic and Lewis basic properties of the silica surface facilitates and accelerates the synthesis of the desired products in high yields. The key advantages of the present method are the excellent yield of the products, low catalyst loading, shorter reaction times, facile work-up, and purification of the products by non-chromatographic methods and the reusability of the catalyst.

机译：本文介绍了一种简单，高效且生态友好的方法，可制备具有生物活性的吡喃并吡唑和3,4-二氢嘧啶-2（1H）-酮。成功合成了钛接枝的聚酰胺型胺基树枝状二氧化硅杂化催化剂，并在Biginelli反应和吡喃并吡咯合成等两个重要的多组分反应中研究了其催化性能。研究表明，树枝状二氧化硅杂化催化剂的晶体孔壁结构使反应物易于吸附。结合二氧化硅表面的路易斯酸性和路易斯碱性，可促进并加速高产率合成所需产物。本方法的关键优点是产物的优异产率，低催化剂负载，较短的反应时间，容易的后处理以及通过非色谱法纯化产物和催化剂的可重复使用性。

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《RSC Advances》 |2015年第123期|共13页
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Sinija P. S.; Sreekumar K.;
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1. Facile synthesis of pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones by a Ti-grafted polyamidoamine dendritic silica hybrid catalyst via a dual activation route [J] . Sinija P. S., Sreekumar K. RSC Advances . 2015,第123期

机译：钛接枝的聚酰胺胺树枝状二氧化硅杂化催化剂通过双活化途径轻松合成吡喃并吡唑和3,4-二氢嘧啶-2（1H）-酮
2. Microwave-promoted facile and rapid solvent-free synthesis procedure for the efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones using ZrO2/SO42- as a reusable heterogeneous catalyst [J] . Gopalakrishnan M, Sureshkumar P, Kanagarajan V, Letters in organic chemistry . 2006,第6期

机译：微波促进的快速简便的无溶剂合成程序，以ZrO2 / SO42-作为可重复使用的多相催化剂，可高效合成3,4-二氢嘧啶-2（1H）-酮和-硫酮
3. Microwave assisted solid phase catalyst-free Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-thione: A green approach, characterization and molecular crystal structures [J] . Minaxi S. Maru Molecular crystals and liquid crystals . 2016,第期

机译：微波辅助固相催化剂 - 不含3,4-二氢嘧啶-2（1H）和3,4-二氢嘧啶-2（1H）：绿色方法，表征和分子晶体结构的3,4-二氢嘧啶-2（1H）和3,4-二氢嘧啶胺催化剂
4. ONE-POT MULTICOMPONENT SYNTHESIS of 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES USING SILICA-SUPPORTED PREYSSLER NANOPARTICLES AS A NOVEL, ECO-FRIENDLY and GREEN CATALYST [C] . Fatemeh F. Bamoharram, Majid M. Heravi, Mina Roshani, 6th international conference on environmental catalysis : Abstract book . 2010

机译：一键多组分合成3,4-二氢吡啶酮N-2（1H）-使用二氧化硅支撑的PreySSLer纳米粒子作为新型，环保和绿色催化剂
5. Synthesis of boron-containing dendritic molecules and polymer-silica hybrid nanoparticles for neutron capture therapy of cancer. [D] . Mollard, Alexis H. A. 2009

机译：用于癌症中子捕获治疗的含硼树枝状分子和聚合物-二氧化硅杂化纳米粒子的合成。
6. Facile Synthesis of Solution-Processed Silica and Polyvinyl Phenol Hybrid Dielectric for Flexible Organic Transistors [O] . Xiong Chen, Yu Zhang, Xiangfeng Guan, 2020

机译：用于柔性有机晶体管的溶液加工二氧化硅和聚乙烯基苯酚混合介电材料的简便合成
7. Silica triflate as an efficient catalyst for the solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones [O] . Farhad Shirini, Katayoun Marjani, Hossein Taherpour Nahzomi 2007

机译：三氟甲磺酸硅酯作为无溶剂合成3,4-二氢嘧啶-2（1H） - 酮的有效催化剂

Facile synthesis of pyranopyrazoles and 3,4-dihydropyrimidin-2(1H)-ones by a Ti-grafted polyamidoamine dendritic silica hybrid catalyst via a dual activation route

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