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In vivo accurate target bio-marking of tumors through in situ biosynthesized fluorescent zinc nanoclusters

机译：通过原位生物合成的荧光锌纳米簇在体内对肿瘤进行准确的靶标生物标记

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摘要

Zinc has important physiological and biochemical functions in the body of human beings, the relevant concentrations of zinc ions were found to considerably decrease when some cancers occurred. Thus, in this contribution, we have explored the possibility of effective imaging or the labeling of cancer cells through in situ biosynthesized zinc nanoclusters. The results demonstrate that we can readily realize the target cellular fluorescence bio-imaging through the in situ biosynthesis of biocompatible zinc nanoclusters from cancerous cells when target cells are cultured with micromolar zinc gluconate solutions. Moreover, in vivo imaging of subcutaneous xenografted tumors in nude mice has also established the validity of this strategy for the rapid and precise target bio-imaging of tumors by subcutaneous injections of zinc gluconate solutions, without significant dissemination to the surrounding normal tissues, resulting from a completely different redox homeostasis of cancer cells from normal cells. This strategy could provide a new ultrasensitive way for rapid & accurate tumor diagnosis/treatment through zinc gluconate, an ideal organic zinc supplement with good biological compatibility and high bioavailability.
机译：锌在人体中具有重要的生理和生化功能，发现某些癌症时，锌离子的相关浓度会大大降低。因此，在这项贡献中，我们探索了通过原位生物合成的锌纳米簇对癌细胞进行有效成像或标记的可能性。结果表明，当用微摩尔葡萄糖酸锌溶液培养靶细胞时，通过从癌细胞中原位生物合成生物相容性锌纳米团簇，我们可以轻松实现靶细胞荧光生物成像。此外，在裸鼠体内进行皮下异种移植肿瘤的体内成像也已经确定了该策略通过皮下注射葡萄糖酸锌溶液对肿瘤进行快速，精确的靶标生物成像的有效性，而不会显着扩散至周围的正常组织，癌细胞与正常细胞完全不同的氧化还原稳态。该策略可通过葡萄糖酸锌（一种具有良好生物相容性和高生物利用度的理想有机锌补充剂）提供一种新的超灵敏方法，以快速，准确地诊断/治疗肿瘤。

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