Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis

Lukashuk O. I.; Abdurakhmanova E. R.; Kondratyuk K. M.; Golovchenko O. V.; Khokhlov K. V.; Brovarets V. S.; Kukhar V. P.

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Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis

机译：将手性2-（氨基烷基）取代基引入5-氨基-1,3-恶唑-4-基膦酸衍生物及其在膦二肽合成中的应用

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Starting from phthalimidoalkanoylamines 1 (amino-protected derivatives of L-alanine, L-valine, and L-leucine), we have suggested a straightforward synthetic route to 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives 5 containing a chiral aminoalkyl substituent on the 2-position of the oxazole ring. Compounds 5 have been further used to obtain phosphonodipeptides 8, 9, and 10 with the original optical purity retained.

机译：从邻苯二甲酰亚胺基链烷胺1（L-丙氨酸，L-缬氨酸和L-亮氨酸的氨基保护衍生物）开始，我们提出了一条简单的合成路线，即可合成含有5个在恶唑环的2-位上的手性氨基烷基取代基。化合物5已经进一步用于获得具有原始光学纯度的膦酰二肽8、9和10。

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《RSC Advances》 |2015年第15期|共9页
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Lukashuk O. I.; Abdurakhmanova E. R.; Kondratyuk K. M.; Golovchenko O. V.; Khokhlov K. V.; Brovarets V. S.; Kukhar V. P.;
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1. Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis [J] . Lukashuk O. I., Abdurakhmanova E. R., Kondratyuk K. M., RSC Advances . 2015,第15期

机译：将手性2-（氨基烷基）取代基引入5-氨基-1,3-恶唑-4-基膦酸衍生物及其在膦二肽合成中的应用
2. N-functionalization of uracil derivatives: synthesis of chiral 2-(3-methyl-5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)- yl)alkanoic acids and their methyl esters [J] . Gondela A, Walczak K Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry . 2005,第12期

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3. Synthesis of new 6-substituent 2-phenyl and 2-(furan-2~yl]-3-phenyl-quinoline-4-carboxylic acid derivatives [J] . Tawassl Tajelsir Hassan Hajalsiddig, Ahmed Elsadig Mohammed Saeed European Journal of Chemistry . 2019,第1期

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6. 2-(3-Aminoalkyl-(alkaryl-aryl-))-1H-124-triazol-5-ylanilines: synthesis and anticonvulsant activity [O] . Yulya MARTYNENKO, Galina BEREST, Nina BUKHTIAYROVA, 2020

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Introduction of chiral 2-(aminoalkyl) substituents into 5-amino-1,3-oxazol-4-ylphosphonic acid derivatives and their use in phosphonodipeptide synthesis

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