Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

Bhardwaj Varun; Gumber Divya; Abbot Vikrant; Dhiman Saurabh; Sharma Poonam

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Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

机译：吡咯：关键医学杂芳族化合物中的一种足智多谋的小分子

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Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities. The combination of different pharmacophores in a pyrrole ring system has led to the formation of more active compounds. Pyrrole containing analogs are considered as a potential source of biologically active compounds that contains a significant set of advantageous properties and can be found in many natural products. The marketed drugs containing a pyrrole ring system are known to have many biological properties such as antipsychotic, beta-adrenergic antagonist, anxiolytic, anticancer (leukemia, lymphoma and myelofibrosis etc.), antibacterial, antifungal, antiprotozoal, antimalarial and many more. Due to the diversity of these analogs in the therapeutic response profile, many researchers have been working to explore this skeleton to its maximum potential against several diseases or disorders. In this review, attempts have been made to disclose various tactical approaches to synthesize pyrrole and pyrrole containing analogs. The structure-activity relationship studies have been discussed along with their therapeutic applications which have been reported during last decade. Some molecules as the main components of the market and clinical trials have also been discussed.

机译：吡咯是众所周知的具有多种活性的生物活性支架。吡咯环系统中不同药效基团的组合导致形成更多活性化合物。含吡咯的类似物被认为是生物活性化合物的潜在来源，其具有重要的有利性质，并且可以在许多天然产物中找到。已知具有吡咯环系统的市售药物具有许多生物学性质，例如抗精神病药，β-肾上腺素能拮抗剂，抗焦虑药，抗癌药（白血病，淋巴瘤和骨髓纤维化等），抗菌，抗真菌，抗原生动物，抗疟疾等等。由于这些类似物在治疗反应方面的多样性，许多研究人员一直在努力探索这种骨架，以最大程度地抵抗多种疾病或病症。在这篇综述中，已经尝试公开各种战术方法来合成吡咯和含吡咯的类似物。已经讨论了结构-活性关系研究及其在最近十年中已报道的治疗应用。还讨论了一些作为市场和临床试验主要成分的分子。

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《RSC Advances》 |2015年第20期|共34页
作者
Bhardwaj Varun; Gumber Divya; Abbot Vikrant; Dhiman Saurabh; Sharma Poonam;
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1. Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics [J] . Bhardwaj Varun, Gumber Divya, Abbot Vikrant, RSC Advances . 2015,第20期

机译：吡咯：关键医学杂芳族化合物中的一种足智多谋的小分子
2. Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors [J] . JiX., SuM., WangJ., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2014,第Null期

机译：设计，合成和生物学评估杂芳基取代的吡咯-2-腈衍生物作为二肽基肽酶IV抑制剂
3. Effect of alkali metal ions on the pyrrole and pyridine π-electron systems in pyrrole-2-carboxylate and pyridine-2-carboxylate molecules: FT-IR, FT-Raman, NMR and theoretical studies [J] . ?widerski G., Wojtulewski S., Kalinowska M., Journal of Molecular Structure . 2011,第1a3期

机译：碱金属离子对吡咯-2-羧酸酯和吡啶-2-羧酸酯分子中吡咯和吡啶π电子体系的影响：FT-IR，FT-Raman，NMR和理论研究
4. Corrosion protection of copper in 0.1 M H_2SO_4 solution by poly(pyrrole)/poly(A/-methyl pyrrole), poly(pyrrole)/poly(A/-phenyl pyrrole) and poly(pyrrole)/poly(A/-methoxyphenyl pyrrole) bilayers [C] . Berrin DURAN, Goezen BEREKET European corrosion congress;EUROCORR 2011 . 2012

机译：聚吡咯/聚（A /甲基吡咯），聚吡咯/聚（A /苯基吡咯）和聚吡咯/聚（A /甲氧基苯基吡咯）在0.1 M H_2SO_4溶液中对铜的腐蚀防护）双层
5. Green chemistry in pyrrole synthesis. I. Solvent effect in Barton-Zard pyrrole synthesis: An improved synthesis of 3,4-dialkyl-1H-pyrrole-2-carboxylates. II. A novel route for the synthesis of pharmaceutically important pyrrole derivatives. [D] . Cherukuri, Sankara R. 2005

机译：吡咯合成中的绿色化学。 I.Barton-Zard吡咯合成中的溶剂作用：3，4-二烷基-1H-吡咯-2-羧酸酯的改进的合成。二。合成重要的吡咯衍生物的新途径。
6. Ab-initio study of pyrrole ring deformation in the indole group of 5-HT interacting with water molecules [O] . Kei Odai, Tohru Sugimoto, Etsuro Ito 2019

机译：5-HT吲哚基与水分子相互作用的吡咯环变形的从头算研究
7. Post Hartree–Fock and DFT Studies on Pyrrole···Nitrogen and Pyrrole···Carbon Monoxide Molecules [O] . R. Kanakaraju, P. Kol 2014

机译：Hartree–Fock和DFT研究吡咯···氮和吡咯···一氧化碳分子
8. Elementary Reactions of Electronically Excited Molecules 6. Quenching of O2(1 delta G) by Amines, Furanes, Pyrroles, and Thiophenes [R] . Hack, W., Voehringer, C., Wagner, H. G. 1985

机译：电子激发分子的基本反应6.胺，呋喃，吡咯和噻吩对O2（1δG）的猝灭

Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

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