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首页> 外文期刊>RSC Advances >The chemical stability and cytotoxicity of carbonyl iron particles grafted with poly(glycidyl methacrylate) and the magnetorheological activity of their suspensions
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The chemical stability and cytotoxicity of carbonyl iron particles grafted with poly(glycidyl methacrylate) and the magnetorheological activity of their suspensions

机译：聚甲基丙烯酸缩水甘油酯接枝的羰基铁颗粒的化学稳定性和细胞毒性及其悬浮液的磁流变活性

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摘要

Carbonyl iron (CI) particles were grafted with poly(glycidyl methacrylate) (PGMA) using atom transfer radical polymerization. Compact coating of PGMA largely improved the chemical stability of the particles in an acid environment and thus reduced the common drawback of bare CI particles. Furthermore, due to possible medical applications of CI-polymer systems for magnetic drug targeting, an in vitro cytotoxicity test was performed using an NIH/3T3 cell line. The cell viability was evaluated by spectrometric assay (MTT). The results show that the prepared particles are not cytotoxic. Moreover, bare CI particles as well as synthesized core-shell particles were suspended in silicone oil, and the rheological behavior of MR suspensions was investigated in controlled shear rate mode under various magnetic field strengths. Dynamic yield stress as a measure of the rigidity of the created internal structures of the suspensions was determined using the Herschel-Bulkley model, which provided a reasonably good fit for rheological data. MR suspensions of PGMA-coated particles exhibited only slightly decreased yield stresses due to their negligibly-affected magnetic performance.
机译：使用原子转移自由基聚合将羰基铁（CI）颗粒接枝聚甲基丙烯酸缩水甘油酯（PGMA）。 PGMA的致密涂层在酸性环境中极大地改善了颗粒的化学稳定性，因此减少了裸CI颗粒的常见缺点。此外，由于CI聚合物系统在磁性药物靶向方面的可能医学应用，因此使用NIH / 3T3细胞系进行了体外细胞毒性测试。通过光谱测定法（MTT）评估细胞活力。结果表明，制备的颗粒没有细胞毒性。此外，将裸露的CI颗粒以及合成的核-壳颗粒悬浮在硅油中，并在各种磁场强度下以受控剪切速率模式研究MR悬浮液的流变行为。使用Herschel-Bulkley模型确定了动态屈服应力，作为衡量悬架内部结构刚度的度量，该模型为流变数据提供了很好的拟合。 PGMA涂层颗粒的MR悬浮液由于其可忽略不计的磁性能而仅表现出略微降低的屈服应力。

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