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首页> 外文期刊>RSC Advances >Selective and sensitive turn-on chemosensor for Al(III) ions applicable in living organisms: nanomolar detection in aqueous medium
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Selective and sensitive turn-on chemosensor for Al(III) ions applicable in living organisms: nanomolar detection in aqueous medium

机译：适用于活生物体的Al（III）离子的选择性和灵敏开启化学传感器：在水性介质中的纳摩尔检测

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摘要

A highly sensitive and selective fluorescent reporter L for Al(III) ions was synthesized and characterized by physicochemical and spectroscopic tools along with single crystal X-ray crystallographic study. This is so far the first report of a crystallographically established fluorescence probe having two rhodamine units which make this probe highly sensitive towards Al(III) ions. L, with a high binding affinity towards Al(III) ions of 3.33 x 10(8) M-2, selectively detects Al(III) ions with almost no interference among various competitive, biologically relevant ions by a strong fluorescence (250 times) as well as colour change in HEPES buffer (1 mM, pH 7.4; acetonitrile/water: 1/3, v/v). The quantum yields (Phi) and molar extinction coefficient (epsilon) of [Al-2(L)(2)(CH3CN)(H2O)(NO3)(4)](NO3)(2) (complex-1) were significantly greater than the sensor L, meaning this probe (L) can detect Al(III) ions at concentrations as low as 3.26 nM, which is comparable with the lowest LOD available in the literature. This non-cytotoxic probe (L) is also an efficient candidate to detect the intercellular distribution of aluminium ions in human lung cancer cells (A549) and Al(III) ions in matured tea leaves.
机译：合成了高灵敏度和选择性的铝（III）离子荧光报告物L，并通过物理化学和光谱学工具以及单晶X射线晶体学研究对其进行了表征。迄今为止，这是晶体学上建立的具有两个若丹明单元的荧光探针的首次报道，该探针使该探针对Al（III）离子高度敏感。 L对Al（III）离子具有3.33 x 10（8）M-2的高结合亲和力，可通过强荧光（250次）选择性检测Al（III）离子，几乎不受各种竞争性生物学相关离子的干扰以及HEPES缓冲液（1 mM，pH 7.4;乙腈/水：1/3，v / v）中的颜色变化。 [Al-2（L）（2）（CH3CN）（H2O）（NO3）（4）]（NO3）（2）（配合物1）的量子产率（Phi）和摩尔消光系数（ε）显着它比传感器L更大，这意味着该探针（L）可以检测到浓度低至3.26 nM的Al（III）离子，这与文献中可用的最低LOD相当。这种非细胞毒性探针（L）也是检测人肺癌细胞（A549）中铝离子和成熟茶叶中Al（III）离子在细胞内分布的有效候选者。

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