Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

Pacula Agata J.; Scianowski Jacek; Aleksandrzak Krzysztof B.

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Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

机译：N-取代的苯并异戊唑-3（2H）-ones的高效合成和抗氧化能力

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A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.

机译：描述了基于邻碘联苯甲酰胺与二硒化锂的反应的N-取代的苯并硒代咪唑-3（2H）-的一种新的，通用的一步合成方法。以高收率（高达98％）获得了一系列烷基和芳基衍生物。通过NMR测试，它们的GPx样抗氧化活性比ebselen高得多。

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《RSC Advances》 |2014年第90期|共4页
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Pacula Agata J.; Scianowski Jacek; Aleksandrzak Krzysztof B.;
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1. Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones [J] . Pacula Agata J., Scianowski Jacek, Aleksandrzak Krzysztof B. RSC Advances . 2014,第90期

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Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones

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