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首页> 外文期刊>RSC Advances >Discrimination of sibutramine and its analogues based on surface-enhanced Raman spectroscopy and chemometrics: toward the rapid detection of synthetic anorexic drugs in natural slimming products
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Discrimination of sibutramine and its analogues based on surface-enhanced Raman spectroscopy and chemometrics: toward the rapid detection of synthetic anorexic drugs in natural slimming products

机译：基于表面增强拉曼光谱和化学计量学的西布曲明及其类似物的区分：旨在快速检测天然减肥产品中的合成厌食药

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Nowadays there is growing concern about the adulteration of synthetic anorexics in natural slimming products (NSP) due to the increasing use of weight-reducing aids. Here, we report surface-enhanced Raman spectroscopy (SERS) coupled with chemometrics for rapid discrimination and detection of sibutramine (SIB) and its analogues (mono-desmethylsibutramine, MDS; di-desmethylsibutramine, DDS) in konjac pressed candy (KPC), which is a NSP used in the treatment of obesity. It has been demonstrated that the two characteristic peaks at 1060 cm(-1) (in SERS spectrum of SIB) and 1407 cm(-1) (in SERS spectrum of MDS) were used to discriminate between SIB, MDS and DDS. Moreover, the two spectra for KPC with MDS and KPC with DDS only exhibited some slight differences. After the second derivative transformation, the differences were much more clear, especially for the peak at 1407 cm(-1) in the SERS spectrum of KPC with MDS. Meanwhile, partial least-squares regression was used for quantitative analysis of the samples. The limit of detection for SIB, MDS and DDS was 5.00 x 10(-8) M, 5.00 x 10(-7) M and 1.00 x 10(-6) M, respectively. Compared with previously reported studies, the method is simple (no pretreatment), less time-consuming and inexpensive, and can be applied to rapidly screen SIB and its analogues in NSP.
机译：如今，由于越来越多地使用减肥辅助手段，人们越来越担心合成厌食症在天然减肥产品（NSP）中的掺假。在这里，我们报告表面增强拉曼光谱（SERS）结合化学计量学，用于快速鉴别和检测魔芋压制糖果（KPC）中的西布曲明（SIB）及其类似物（单去甲基西布曲明，MDS;二去甲基西布曲明，DDS）。是用于治疗肥胖的NSP。已经证明，使用1060 cm（-1）（在SIB的SERS光谱中）和1407 cm（-1）（在MDS的SERS光谱中）这两个特征峰来区分SIB，MDS和DDS。此外，带有MDS的KPC和带有DDS的KPC的两个光谱仅表现出一些细微的差异。经过二阶导数转换后，差异更加明显，尤其是对于带有MDS的KPC的SERS光谱中的1407 cm（-1）峰。同时，将偏最小二乘回归用于样品的定量分析。 SIB，MDS和DDS的检出限分别为5.00 x 10（-8）M，5.00 x 10（-7）M和1.00 x 10（-6）M。与以前报道的研究相比，该方法简单（无需预处理），耗时少且便宜，可用于在NSP中快速筛选SIB及其类似物。

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