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首页> 外文期刊>RSC Advances >Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion
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Use of multifunctional phosphorylated PAMAM dendrimers for dentin biomimetic remineralization and dentinal tubule occlusion

机译：多功能磷酸化PAMAM树状聚合物在牙本质仿生再矿化和牙本质小管阻塞中的应用

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摘要

The disequilibrium between demineralization and remineralization of teeth, especially of dentin, may lead to serious consequences like dental caries that are considered to affect people's quality of life. The employment of biomimetic analogs of proteins to duplicate biomineralization, which is a well-regulated process mediated by extracellular matrix proteins, may provide new insights to solve these problems. Here we report the use of a modified multifunctional dendrimer, synthesized by the introduction of phosphate groups via a Mannich-type reaction onto poly(amidoamine) (PAMAM) dendrimers, to biomimetically remineralize dentin. The phosphorylated PAMAM dendrimers were demonstrated to act, along with an amorphous calcium phosphate stabilizing agent, polyacrylic acid (PAA), as biomimetic analogs of noncollagenous proteins to induce the remineralization of demineralized dentin. Phosphorylated PAMAM dendrimers treated demineralized dentin discs were immersed in a remineralizing solution containing PAA for up to 7 days. The success of this remineralization was examined using attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and electron microscopy. These results showed that demineralized dentinal collagen fibrils were successfully phosphorylated by the treatment of phosphorylated PAMAM dendrimers and embedded with calcium-deficient hydroxyapatite after remineralization. The surfaces of demineralized dentin discs were covered with newly induced crystals and the patent dentinal tubules were occluded. A good biocompatibility was also determined. Thus, phosphorylated PAMAM dendrimers could be applied as a minimally invasive method of management of dentin caries, employed to improve the resin-dentin bonding stability and also be used in the treatment of dentin hypersensitivity.
机译：牙齿（尤其是牙本质）的脱矿质和再矿化之间的不平衡可能会导致严重的后果，例如龋齿，被认为会影响人们的生活质量。运用仿生蛋白质类似物来复制生物矿化作用是由细胞外基质蛋白介导的良好调控的过程，可能为解决这些问题提供新的见解。在这里，我们报告了使用经过修饰的多功能树枝状聚合物，通过将曼尼希型反应中的磷酸基团引入到聚（酰胺胺）（PAMAM）树枝状聚合物上来合成，以仿生矿化牙本质。磷酸化的PAMAM树状大分子与无定形磷酸钙稳定剂聚丙烯酸（PAA）一起作为非胶原蛋白的仿生类似物起作用，以诱导脱矿质牙本质的再矿化。将经过磷酸化的PAMAM树状聚合物处理的脱矿牙本质牙盘浸入含有PAA的再矿化溶液中长达7天。使用衰减全反射傅里叶变换红外光谱（ATR-FTIR），X射线衍射（XRD），能量色散X射线光谱（EDS）和电子显微镜检查了这种再矿化的成功。这些结果表明，脱矿质的牙本质胶原原纤维通过磷酸化的PAMAM树状聚合物的处理成功地被磷酸化，并在矿化后被钙缺乏的羟基磷灰石包埋。脱矿质牙本质盘的表面覆盖有新诱导的晶体，并封闭了牙本质小管。还确定了良好的生物相容性。因此，磷酸化的PAMAM树状聚合物可以用作牙本质龋病的微创方法，用于改善树脂-牙本质结合的稳定性，也可以用于牙本质过敏症的治疗。

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