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Hybrid magnetic scaffolds of gelatin-siloxane incorporated with magnetite nanoparticles effective for bone tissue engineering

机译：明胶-硅氧烷的杂化磁性支架与磁铁矿纳米粒子的结合对骨组织工程有效

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Magnetism-induced applications of nanomaterials and scaffolds are currently gaining great interest for their potential applications in tissue repair and disease treatment. Here, we prepare novel magnetic scaffolds of gelatin-siloxane (GS) hybrids for bone repair and regeneration by incorporating magnetite nanoparticles (MNs). MNs were incorporated during the sol-gel process of the organic-inorganic hybrids, and highly porous scaffolds were achieved via the free-drying method. The MNs incorporated up to 3 wt% were shown to uniformly distribute within the GS matrix. The incorporated MNs significantly improved the mechanical properties of the scaffolds, including resistance to static load and dynamic storage modulus (from 100 kPa to 450 kPa). The scaffolds presented superparamagnetic behaviors, and the saturation magnetization increased with increasing MN content. The GS-MN scaffolds showed excellent bone-bioactivity, inducing apatite minerals rapidly in a body simulating medium. Rat mesenchymal stem cells cultured on the scaffolds spread better on the MN-incorporated magnetic scaffolds, and cell proliferation significantly improved on the magnetic scaffolds with respect to MN-free scaffolds. Osteogenic differentiation, as assessed by alkaline phosphatase activity of cells, was significantly higher in the magnetic scaffolds, and, furthermore, the cellular mineralization behavior also greatly improved with the incorporation of MNs. The results suggest that the MNs incorporated at small concentrations are effective in stimulating cell growth and osteogenic differentiation in the GS hybrid porous scaffolds, and thus the magnetic hybrid scaffolds may be useful for bone tissue engineering.
机译：磁性材料诱导的纳米材料和支架的应用目前因其在组织修复和疾病治疗中的潜在应用而引起人们的极大兴趣。在这里，我们通过掺入磁铁矿纳米颗粒（MNs），制备了明胶-硅氧烷（GS）杂化物的新型磁性支架，用于骨修复和再生。在有机-无机杂化物的溶胶-凝胶过程中掺入了MN，并且通过自由干燥方法获得了高度多孔的支架。掺入至多3重量％的MN显示出在GS基质内均匀分布。并入的MN显着改善了支架的机械性能，包括对静态载荷和动态储能模量（从100 kPa到450 kPa）的抵抗力。支架呈现超顺磁行为，并且饱和磁化强度随MN含量的增加而增加。 GS-MN支架具有出色的骨骼生物活性，可在人体模拟培养基中快速诱导磷灰石矿物质。培养在支架上的大鼠间充质干细胞在掺有MN的磁性支架上分布更​​好，并且相对于不含MN的支架，磁性支架上的细胞增殖明显改善。通过细胞的碱性磷酸酶活性评估成骨分化在磁性支架中显着更高，此外，通过掺入MN，细胞矿化行为也大大改善。结果表明，以低浓度掺入的MN可有效刺激GS杂化多孔支架中的细胞生长和成骨分化，因此磁性杂化支架可用于骨组织工程。

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