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首页> 外文期刊>RSC Advances >Liposomal nanohybrid cerasomes for controlled insulin release
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Liposomal nanohybrid cerasomes for controlled insulin release

机译：脂质体纳米杂化体用于控制胰岛素释放

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摘要

This study reported a facile fabrication of a reproducible and injectable cerasomal insulin formulation by encapsulating insulin into cerasomes via one-step construction. Notably, a wide range of the insulin release profiles was achieved by altering vesicle composition through incorporating the phospholipid of DPPC into cerasomes, and the mixed cerasomes showed excellent storage stability when the percentage content of DPPC was lower than 50%. It was found that the subcutaneous administration of the insulin-loaded cerasomes resulted in a reduction of blood glucose levels in a rat model of type I diabetes and the hypoglycemic effect was found to be composition dependent. The use of cerasomes significantly improved glucose tolerance from 6 hours (free insulin) to more than 16 hours (insulin-loaded cerasomes). Moreover, the insulin-loaded cerasomes displayed a prolonged and stable glucose-lowering profile over a period of over 12 hours compared with the insulin-loaded liposomes. These findings demonstrate that cerasomes have good potential for the use in an effective controlled release delivery system of insulin as well as other proteins with short half-life time.
机译：这项研究报告说，通过一步构建将胰岛素包封到体中，可以简便地制造可重现和注射的陶瓷体胰岛素制剂。值得注意的是，通过将DPPC的磷脂掺入到脂质体中来改变囊泡组成，从而获得了广泛的胰岛素释放曲线，并且当DPPC的含量低于50％时，混合的脂质体显示出优异的储存稳定性。发现在I型糖尿病大鼠模型中皮下给予胰岛素的脂质体可导致血糖水平降低，并且发现降血糖作用是组成依赖性的。从6小时（游离胰岛素）到超过16小时（负载胰岛素的血清体），使用陶瓷体显着提高了葡萄糖耐量。此外，与负载胰岛素的脂质体相比，负载胰岛素的血清体在超过12小时的时间内显示出延长且稳定的降糖曲线。这些发现表明，陶瓷小体具有用于胰岛素以及其他具有短半衰期的蛋白质的有效控释递送系统中的良好潜力。

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