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首页> 外文期刊>RSC Advances >Triethanolamine as an inexpensive and efficient catalyst for the green synthesis of novel 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under ultrasound irradiation in water and their antibacterial activity
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Triethanolamine as an inexpensive and efficient catalyst for the green synthesis of novel 1H-pyrazolo[1,2-a]pyridazine-5,8-diones under ultrasound irradiation in water and their antibacterial activity

机译：三乙醇胺是一种廉价有效的催化剂，可在水中超声辐射下绿色合成新型1H-吡唑并[1,2-a]哒嗪-5,8-二酮及其抗菌活性

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摘要

Triethanolamine was found to be an efficient catalyst for the synthesis of new 1H-pyrazolo[1,2-a]pyridazine-5,8-diones by a one-pot reaction of maleic hydrazide, with aromatic aldehydes and malononitrile in H2O under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of H2O as a green solvent. To assess their antibacterial activity, all the synthesized compounds were dissolved in DMSO and subjected to biological evaluation using the disc diffusion method against 3 Gram positive and 3 Gram negative bacteria.
机译：发现三乙醇胺是超声波照射下马来酰肼与芳族醛和丙二腈的一锅反应，是合成新的1H-吡唑并[1,2-a]哒嗪-5,8-二酮的有效催化剂。 。该方法的优点是使用廉价且容易获得的催化剂，易于后处理，提高的收率以及使用H2O作为绿色溶剂。为了评估它们的抗菌活性，将所有合成的化合物溶解在DMSO中，并使用圆盘扩散法对3革兰氏阳性和3革兰氏阴性细菌进行生物学评估。

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