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首页> 外文期刊>RSC Advances >Hyaluronic acid-mediated one-pot facile synthesis of a sensitive and biocompatible Gd2O3 nanoprobe for MR imaging in vivo
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Hyaluronic acid-mediated one-pot facile synthesis of a sensitive and biocompatible Gd2O3 nanoprobe for MR imaging in vivo

机译：透明质酸介导的灵敏且生物相容的Gd2O3纳米探针的一锅式便捷合成，用于体内MR成像

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摘要

MR contrast agents play a crucial role in the early diagnosis of various diseases, and many nanoprobes with versatile properties have been developed. However, in order to seek high sensitivity, the biocompatibility and systemic toxicity assessment of the nanoprobes have attracted much less attention. To meet clinical requirements, it is highly desirable to develop a highly sensitive and biocompatible nanoprobe using a facile procedure. Herein, we report a sensitive and biocompatible Gd2O3 nanoprobe using hyaluronic acid (HA) via a one-pot facile synthesis. HA not only endows the nanoprobe with excellent biocompatibility, but also gives a synergistic effect for improving the sensitivity of the nanoprobe in the aspects of increasing rotational correlation time, water exchange rate and the ratio of surface Gd3+ to the inner ones. What's more, the nanoprobe has specific ability for adrenal gland MR imaging. These results suggest that the HA-Gd2O3 nanoprobe has a potentially promising application in MR imaging in vivo.
机译：MR造影剂在各种疾病的早期诊断中起着至关重要的作用，并且已经开发出许多具有多功能特性的纳米探针。然而，为了寻求高灵敏度，纳米探针的生物相容性和系统毒性评估吸引了较少的关注。为了满足临床要求，非常希望使用简便的方法开发高度敏感和生物相容的纳米探针。在这里，我们报告通过一锅法容易合成的透明质酸（HA）的敏感和生物相容性Gd2O3纳米探针。 HA不仅赋予纳米探针优异的生物相容性，而且在增加旋转相关时间，水交换速率和表面Gd3 +与内部表面的比率方面，均具有协同效应，可提高纳米探针的灵敏度。此外，纳米探针对肾上腺MR成像具有特定的能力。这些结果表明，HA-Gd2O3纳米探针在体内MR成像中具有潜在的应用前景。

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