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首页> 外文期刊>RSC Advances >Single walled carbon nanotubes reinforced mineralized hydroxyapatite composite coatings on titanium for improved biocompatible implant applications
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Single walled carbon nanotubes reinforced mineralized hydroxyapatite composite coatings on titanium for improved biocompatible implant applications

机译：单壁碳纳米管在钛上增强了矿化的羟基磷灰石复合涂层，以改善生物相容性植入物的应用

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摘要

A surface coating strategy encompassing the use of bioactive trace elements and reinforcing material will have a significant influence on the mechanical and osseointegration properties of bioceramic coated implants. Here, we developed mineral substituted hydroxyapatite (M-HAP) and carbon nanotube reinforced mineralized hydroxyapatite (CNT/M-HAP) composite coating on titanium (Ti) by pulsed electrodeposition which is a promising approach to produce bioimplants with better osseointegration capacity and improved mechanical properties. The role of CNT and minerals like strontium, magnesium and zinc, in enhancing the mechanical and biological properties of the HAP coating was investigated using various techniques. The structural and morphological analyses were carried out using Fourier transform infrared spectroscopy, X-ray diffraction analysis, scanning electron microscopy, energy dispersive X-ray analysis and elemental mapping. The mechanical characterization results revealed enhanced adhesion strength for the composite coating. Also, an improved viability of osteoblast cells was observed in vitro on the CNT/M-HAP composite coating. The ability of the composite coated Ti implant to induce bone formation was evaluated in vivo in Wistar rats. Thus, the as-developed composite coated Ti that combines the good osteoconductivity of M-HAP together with the mechanical strength of CNT can be used as a potential implant material for orthopedic applications.
机译：包括使用生物活性微量元素和增强材料在内的表面涂层策略将对生物陶瓷涂层植入物的机械和骨整合特性产生重大影响。在这里，我们通过脉冲电沉积在钛（Ti）上开发了矿物取代的羟基磷灰石（M-HAP）和碳纳米管增强的矿化羟基磷灰石（CNT / M-HAP）复合涂层，这是生产具有更好骨整合能力和改善机械性能的生物植入物的有前途的方法属性。使用各种技术研究了碳纳米管和矿物质（如锶，镁和锌）在增强HAP涂层的机械和生物学特性方面的作用。使用傅立叶变换红外光谱，X射线衍射分析，扫描电子显微镜，能量色散X射线分析和元素图谱进行结构和形态分析。力学表征结果表明复合涂层的粘合强度提高。此外，在体外在CNT / M-HAP复合涂层上观察到成骨细胞活力的提高。在Wistar大鼠体内评估了复合涂层Ti植入物诱导骨形成的能力。因此，结合了M-HAP良好的骨传导性和CNT的机械强度的复合涂层Ti可以作为整形外科的潜在植入材料。

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