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首页> 外文期刊>RSC Advances >Synthesis and characterization of a photocrosslinkable chitosan-gelatin hydrogel aimed for tissue regeneration
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Synthesis and characterization of a photocrosslinkable chitosan-gelatin hydrogel aimed for tissue regeneration

机译：用于组织再生的可光交联的壳聚糖-明胶水凝胶的合成与表征

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In the area of tissue engineering different approaches have been studied, so far, for promoting regeneration or replacement of damaged tissues. Among the different materials developed, hydrogels, due to their biocompatibility and similarities with the native extracellular matrix, have emerged as suitable candidates for being used for different therapeutic purposes. Herein, photocrosslinkable hydrogels, composed by chitosan methacrylamide (ChMA) and gelatin methacrylamide (GelMA) were crosslinked by ultraviolet (UV) light, using Irgacue 2959 as photoinitiator. The morphological, physicochemical and biological properties of the hydrogels were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and nuclear magnetic resonance. The obtained results demonstrated that the developed hydrogels possess suitable properties for being used as 3D constructs on several areas of tissue engineering. Furthermore, these properties may allow their future application as space filling agents or as delivery vehicles of bioactive molecules and cells.
机译：迄今为止，在组织工程领域中，已经研究了用于促进受损组织的再生或替换的不同方法。在开发的不同材料中，由于其生物相容性和与天然细胞外基质的相似性，水凝胶已成为适合用于不同治疗目的的候选物。在此，使用Irgacue 2959作为光引发剂，将由壳聚糖甲基丙烯酰胺（ChMA）和明胶甲基丙烯酰胺（GelMA）组成的可光交联水凝胶通过紫外线（UV）交联。通过扫描电子显微镜，傅立叶变换红外光谱和核磁共振表征了水凝胶的形态，理化和生物学特性。获得的结果证明，开发的水凝胶具有适合用作组织工程几个领域的3D构造的特性。此外，这些性质可以使其将来用作空间填充剂或生物活性分子和细胞的输送载体。

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