• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Single-protein-based theranostic nanosystem within sub-10 nm scale for tumor imaging and therapy
【24h】

Single-protein-based theranostic nanosystem within sub-10 nm scale for tumor imaging and therapy

机译：小于10 nm规模的基于单蛋白的治疗肿瘤纳米系统，用于肿瘤成像和治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A single-protein-based theranostic nanosystem (SPTN) based on non-covalent interaction between bovine serum albumin (BSA), gadolinium (Gd) and the anticancer hydrophobic drug doxorubicin (DOX) was designed and developed via a facile, environmentally benign approach. Gd was incorporated into the structure of BSA via a simple biomineralization process, while DOX was encapsulated in Gd-BSA nanoparticles via hydrophobic interaction between DOX and BSA, as well as a coordination effect between DOX and Gd. The whole SPTN system was kept in one single BSA molecule to form a single protein based nanosystem with an overall size of around 7 nm favorable for potential renal clearance. The SPTN nanosystem showed not only robust biocompatibility, excellent T-1-weighted MR imaging effect but also fine pH-responsive drug release characteristics. Furthermore, in vivo therapeutic efficacy experiment showed that the nanoparticle DOX-Gd-BSA had an obvious therapeutic efficacy toward hepatoma tumor bearing mice.
机译：基于牛血清白蛋白（BSA），ado（Gd）和抗癌疏水性药物阿霉素（DOX）之间的非共价相互作用，基于单蛋白的治疗诊断纳米系统（SPTN）是通过一种简便，环保的方法设计和开发的。通过简单的生物矿化过程将Gd掺入BSA的结构中，而DOX通过DOX和BSA之间的疏水相互作用以及DOX和Gd之间的配位作用被封装在Gd-BSA纳米颗粒中。将整个SPTN系统保存在一个单一的BSA分子中，以形成一个单一的基于蛋白质的纳米系统，其总体尺寸约为7 nm，有利于潜在的肾脏清除。 SPTN纳米系统不仅显示出强大的生物相容性，出色的T-1加权MR成像效果，而且还具有出色的pH响应药物释放特性。此外，体内治疗效果实验表明，纳米粒DOX-Gd-BSA对荷瘤小鼠具有明显的治疗效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号