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首页> 外文期刊>RSC Advances >Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors
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Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors

机译：奎宁酸衍生物作为针对T细胞受体的免疫抑制剂的平行合成和生物学进化

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摘要

A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro binding measurements of atomic force spectroscopy further indicated that the blocking effect of Cyn-1324 between CD28 and CD80 was about 31 + 4%. In vivo animal tests also confirmed that Cyn-1324 can reduce the allergic responses from ovalbumin-induced mice with little toxicity. Based on these observations, Cyn-1324 can be a mild immuno-suppressive candidate for future drug development.
机译：建立了一种简单的合成奎宁酸衍生物的方案，并研究了它们对T细胞的生物学进化。结果表明，其中一种衍生物Cyn-1324对T细胞毒性低，对减少T细胞免疫反应的信号2的影响很大。原子力光谱的体外结合测量进一步表明，Cyn-1324在CD28和CD80之间的阻断作用约为31 + 4％。体内动物试验还证实，Cyn-1324可以降低卵白蛋白诱导的小鼠的过敏反应，且毒性很小。基于这些观察，Cyn-1324可能是未来药物开发的轻度免疫抑制候选药物。

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