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首页> 外文期刊>RSC Advances >Utilizing an aggregate forming microenvironment sensitive coumarin-cholesterol conjugate as a sensor of pluronic organization and micro-polarity
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Utilizing an aggregate forming microenvironment sensitive coumarin-cholesterol conjugate as a sensor of pluronic organization and micro-polarity

机译：利用形成聚集体的微环境敏感香豆素-胆固醇共轭物作为普卢尼克组织和微极性的传感器

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摘要

A new fluorescent cholesterol molecular probe, 3-acetyl-7-(diethylamino)-2H-chromen-2-one attached cholesterol (Cum-Chl), has recently been introduced as a reporter of micro-heterogeneous media. The H-aggregate forming ability of Cum-Chl provides a useful fluorescence parameter, I-monomer/I-aggregate to understand the micro-polarity of anisotropic media. Pluronics are surfactant based polymeric anisotropic media having important applications in therapeutics. Being a sensitive indicator of pluronics micro-polarity I-monomer/I-aggregate can help in selecting pluronics for medicinal purposes. Additionally, temperature and concentration induced sol-gel transition of pluronics (P123, F127) have been successfully investigated by Cum-Chl using its I-monomer/I-aggregate value, along with other conventional fluorescence parameters. Finally, this molecular probe, Cum-Chl emerges as a good sensor of progressive polymeric association and micro-polarity of pluronics.
机译：最近引入了一种新型的荧光胆固醇分子探针，即3-乙酰基-7-（二乙氨基）-2H-铬-2-酮连接的胆固醇（Cum-Chl），作为微异质介质的报道分子。 Cum-Chl的H聚集体形成能力提供了有用的荧光参数I-单体/ I聚集体，以了解各向异性介质的微极性。 Pluronics是基于表面活性剂的聚合物各向异性介质，在治疗中具有重要的应用。作为普朗尼克斯微极性I-单体/ I-聚集体的敏感指标，可以帮助您选择用于医学用途的普朗尼克斯。另外，Cum-Chl已成功使用其I-单体/ I-聚集值以及其他常规荧光参数，成功地研究了温度和浓度诱导的Pluronics（P123，F127）的溶胶-凝胶转变。最终，这种分子探针Cum-Chl成为了渐进聚合物缔合和微极性的微极性的良好传感器。

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