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首页> 外文期刊>RSC Advances >Injectable conducting interpenetrating polymer network hydrogels from gelatin-graft-polyaniline and oxidized dextran with enhanced mechanical properties
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Injectable conducting interpenetrating polymer network hydrogels from gelatin-graft-polyaniline and oxidized dextran with enhanced mechanical properties

机译：明胶接枝聚苯胺和氧化葡聚糖的注射导电互穿聚合物网络水凝胶，具有增强的机械性能

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摘要

Electrically conductive hydrogels have great potential for biomedical applications. However, they usually exhibited poor mechanical properties. We present a simple approach to prepare injectable conductive interpenetrating polymer network (IPN) hydrogels with enhanced mechanical properties. The in situ forming IPN conductive hydrogels were based on gelatin-graft-polyaniline and carboxymethyl-chitosan, which were crosslinked with oxidized dextran via Schiff base at physiological conditions. Storage modulus of the injectable conductive IPN hydrogels was greatly increased. Gelation time, swelling ratio, pore size and conductivity of these injectable hydrogels were adjusted by polyaniline content. Electroactivity of the hydrogels was studied by UV-vis and cyclic voltammetry. Cytocompatibility of the hydrogels was investigated by cell adhesion and proliferation of C2C12 myoblasts and adipose-derived mesenchymal stem cells. The in vivo biocompatibility of the hydrogels was confirmed by H&E staining. These injectable conductive hydrogels with good mechanical properties and biocompatibility as bioactive biomaterials have great potential for drug delivery and tissue engineering.
机译：导电水凝胶在生物医学应用中具有巨大潜力。但是，它们通常表现出较差的机械性能。我们提出了一种简单的方法来制备具有增强的机械性能的可注射导电互穿聚合物网络（IPN）水凝胶。原位形成的IPN导电水凝胶基于明胶接枝聚苯胺和羧甲基壳聚糖，它们在生理条件下通过Schiff碱与氧化葡聚糖交联。可注射的导电IPN水凝胶的储能模量大大提高。这些可注射水凝胶的胶凝时间，溶胀率，孔径和电导率通过聚苯胺含量进行调节。通过紫外可见和循环伏安法研究了水凝胶的电活性。通过C2C12成肌细胞和脂肪间充质干细胞的细胞粘附和增殖研究了水凝胶的细胞相容性。 H＆E染色证实了水凝胶的体内生物相容性。这些具有良好机械性能和生物相容性的可注射导电水凝胶作为生物活性生物材料在药物输送和组织工程方面具有巨大潜力。

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