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首页> 外文期刊>RSC Advances >In vivo cytotoxicity of MgO-doped nanobioactive glass particles and their anticorrosive coating on Ti-6Al-4V and SS304 implants for high load-bearing applications
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In vivo cytotoxicity of MgO-doped nanobioactive glass particles and their anticorrosive coating on Ti-6Al-4V and SS304 implants for high load-bearing applications

机译：MgO掺杂的纳米生物活性玻璃颗粒及其在高负荷应用的Ti-6Al-4V和SS304植入物上的防腐涂层的体内细胞毒性

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摘要

In this study, magnesium-doped nanobioactive glass (NBG) composites (SiO2-CaO-P2O5-MgO) were prepared by simple sol-gel method, which were characterized and coated on Ti alloy (Ti-6Al-4V) and stainless steel (SS304) implants by spin-coating technique. The prepared nanocomposite shows amorphous nature and spherical morphology with particle size of less than 100 nm. The adsorption and desorption isotherms showed the prepared nanocomposites to be in mesoporous range with a specific surface area of 104.1 m(2) g(-1). The coated implant was found to have a uniform structure without any cracks and pores. Magnesium-doped NBG-coated Ti implants show high corrosion resistance and hardness. In addition, formation of bone-like apatite layer on the coated implant was found to be high in magnesium-doped NBG particles. In addition, in vivo toxicity of the glasses was studied in zebrafish (Danio rerio) embryos, and the results confirmed significant toxicity at higher concentration. Hence, magnesium-doped NBG-coated implant is found to be a potential nanocomposite for high load-bearing applications with better anticorrosive property and long-term stability.
机译：本研究采用简单的溶胶-凝胶法制备了镁掺杂的纳米生物玻璃（SiO2-CaO-P2O5-MgO）复合材料，并对其进行了表征并涂覆在钛合金（Ti-6Al-4V）和不锈钢（ SS304）通过旋涂技术植入。制备的纳米复合材料显示出小于100nm的粒径的无定形性质和球形形态。吸附和解吸等温线显示制备的纳米复合材料处于介孔范围内，比表面积为104.1 m（2）g（-1）。发现涂覆的植入物具有均匀的结构，没有任何裂纹和孔。掺镁的NBG涂层的Ti植入物具有很高的耐腐蚀性和硬度。另外，发现在掺杂的植入物上的骨状磷灰石层的形成在掺镁的NBG颗粒中较高。此外，还对斑马鱼（Danio rerio）胚胎中的玻璃进行了体内毒性研究，结果证实了在较高浓度下该玻璃具有明显的毒性。因此，发现掺杂镁的NBG涂层植入物是潜在的纳米复合材料，具有较高的防腐性能和长期稳定性，可用于高承载应用。

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