One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivatives

Dong Hong-Ru; Gao Zhong-Lian; Li Rong-Shan; Hu Yi-Ming; Dong Heng-Shan; Xie Zhi-Xiang

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One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivatives

机译：一锅合成5H-1,3,4-噻二唑并[3,2-a]嘧啶-5-酮衍生物

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A novel and efficient one-pot method has been developed for the synthesis of 2-substituted-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivative by the combination of [3 + 3] cycloaddition, reduction, deamination reactions. The fused heterocyclic compounds 2-substituted-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-ones was synthesized by the diversity-oriented catalysis. As an extension of the synthetic methodology, some 4H-pyrido[1,2-a]pyrimidin-4-one 4a-c was synthesized. The pi-pi accumulation structure of supramolecular self-assembly was discussed in the crystal.

机译：通过[3 + 3]的组合，开发了一种新颖且有效的一锅法，用于合成2-取代的-5H-1,3,4-噻二唑并[3,2-a]嘧啶-5-酮衍生物。环加成，还原，脱氨基反应。通过多样性取向催化合成了稠合的杂环化合物2-取代的-5H-1,3,4-噻二唑并[3,2-a]嘧啶-5-酮。作为合成方法的扩展，合成了一些4H-吡啶并[1,2-a]嘧啶-4-一4a-c。在晶体中讨论了超分子自组装的pi-pi积累结构。

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《RSC Advances》 |2014年第99期|共5页
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Dong Hong-Ru; Gao Zhong-Lian; Li Rong-Shan; Hu Yi-Ming; Dong Heng-Shan; Xie Zhi-Xiang;
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1. One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivatives [J] . Dong Hong-Ru, Gao Zhong-Lian, Li Rong-Shan, RSC Advances . 2014,第99期

机译：一锅合成5H-1,3,4-噻二唑并[3,2-a]嘧啶-5-酮衍生物
2. Synthesis of new derivatives of 1-alkyl-2-aryl-1H-2,3-dihydroimidazo(1,2-a)pyrimidin-5-one active in CNS. Part 2. Synthesis and results of preliminary pharmacological screening of 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo(1,2-a)pyrimi [J] . Matosiuk D, Tkaczynski T, Stefanczyk J Acta Poloniae Pharmaceutica: Durg Research . 1999,第3期

机译：在CNS中具有活性的1-烷基-2-芳基-1H-2,3-二氢咪唑并（1,2-a）嘧啶-5-新衍生物的合成第2部分。7-（取代）氨基-1-烷基-2-芳基-1H-2,3-二氢咪唑并（1,2-a）嘧啶的合成及初步药理筛选的结果
3. Synthesis and transformations of hydrazine substituted 6-fluoro derivatives of 1,3,4-thiadiazolo[3,2-a]pyrimidine [J] . Kukaniev M.A., Párkányi C. Journal of Heterocyclic Chemistry: The International Journal of Heterocyclic Chemistry . 2011,第6期

机译：1,3,4-噻二唑并[3,2-a]嘧啶的肼取代6-氟衍生物的合成和转化
4. Catalytic performance of CuO@SiO2 for one-pot synthesis of pyrimidine derivative,ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate [C] . A H Cahyana, S P Sari, B Ardiansah International Symposium on Current Progress in Functional Materials . 2019

机译：CuO / 2-oxo-4-苯基-1,2,3,4-四氢嘧啶-5-羧酸乙烯基二罐合成CuO / 2-氧代-4-苯基-1,2,3,4-四氢嘧啶-5-羧酸酯的催化性能
5. I. SYNTHETIC APPROACHES TO SUBSTITUTED 2-OXABICYCLO(3.2.1)OCTANE DERIVATIVES AND II. THE SYNTHESIS OF 1-SUBSTITUTED DERIVATIVES OF ANHYDRO (3-CHLOROACETYL-2-HYDROXYIMIDAZO(1,2-A)PYRIDINIUM HYDROXIDE). [D] . FRIEDMAN, ALAN E. 1973

机译：I.取代2-氧杂双环（3.2.1）正己烷衍生物的合成方法和II。合成1-取代的酸酐（3-氯乙酰基-2-羟基咪唑并（1,2-A）吡啶鎓氢氧化物）。
6. Synthesis and molecular modeling of bis(3-(piperazine-1-yl)propyl)tungstate (BPPT) nanoparticles and its first catalytic application for one-pot synthesis of 4H-chromene derivatives [O] . Khalil Eskandari, Yaghoub Pourshojaei, Fatemeh Haghani, 2019

机译：双（3-（哌嗪-1-基）丙基）钨酸（BPPT）纳米粒子的合成分子模型及其在4H-色烯衍生物一锅法合成中的首次催化应用
7. Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives [O] . Dong Cai, Zhi-Hua Zhang, Yu Chen, 2015

机译：一些5H-噻唑并[3,2-a]嘧啶-5-酮和磺酸衍生物的合成，抗菌和抗结核活性

One-pot synthesis of 5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one derivatives

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