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首页> 外文期刊>RSC Advances >Graphene-hemin hybrid nanosheets as a label-free colorimetric platform for DNA and small molecule assays
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Graphene-hemin hybrid nanosheets as a label-free colorimetric platform for DNA and small molecule assays

机译：石墨烯-血红素杂化纳米片作为DNA和小分子测定的无标记比色平台

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摘要

Here we report a novel label-free colorimetric biosensing strategy based on graphene-hemin hybrid nanosheets (GHs) for DNA and small molecule assays. GHs were synthesized by a simple wet-chemical method and they possess excellent properties from both graphene and hemin. When mixed with ssDNA, GHs exhibited enhanced catalytic activity in the presence of ABTS and H2O2. In contrast, the GHs mixed with dsDNA had lower catalytic activity than those mixed with ssDNA. On the basis of this property of the GHs, a novel universal label-free colorimetric method was proposed. This simple strategy has advantages over conventional assays because of its label-free design, extreme operational simplicity and low cost. DNA and cocaine were studied as model cases and the results revealed that the developed method had potential for becoming a universal platform for detection of a wide range of analytes.
机译：在这里，我们报告了一种基于石墨烯-血红素混合纳米片（GHs）的新颖的无标记比色生物传感策略，用于DNA和小分子测定。 GHs是通过简单的湿化学方法合成的，具有石墨烯和血红素的优良性能。当与ssDNA混合时，GH在ABTS和H2O2存在下表现出增强的催化活性。相反，与dsDNA混合的GHs的催化活性比与ssDNA混合的GHs的催化活性低。基于GHs的这一特性，提出了一种新的通用的无标记比色法。这种简单的策略由于其无标记的设计，极其简单的操作和低成本而具有优于常规测定的优点。以DNA和可卡因为模型案例进行了研究，结果表明，开发的方法有可能成为检测多种分析物的通用平台。

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