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首页> 外文期刊>RSC Advances >From micron to nano-curcumin by sophorolipid co-processing: highly enhanced bioavailability, fluorescence, and anti-cancer efficacy
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From micron to nano-curcumin by sophorolipid co-processing: highly enhanced bioavailability, fluorescence, and anti-cancer efficacy

机译：通过槐糖脂共处理，从微米到纳米姜黄素：大大提高了生物利用度，荧光和抗癌功效

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摘要

Co-sonication of curcumin and acidic sophorolipid in aqueous solution is shown to lead to a dramatic enhancement of curcumin bioavailability through size reduction and encapsulation. The interaction between the two is studied and discussed based on optical absorption, photoluminescence, dynamic light scattering (DLS), zeta potential, FE-SEM, TEM, Infrared spectroscopy and X-ray diffraction measurements. The cytotoxicity effects of curcumin on breast cancer cell lines, MCF-7 and MDA-MB-231, are shown to be significantly enhanced by the formation of its complex with sophorolipid. The relative cytotoxicity of curcumin with its SL(A) complex is more due to the presence of the glucose moiety. The results further suggest that sophorolipid based formulations, which solubilize and nano-encapsulate curcumin after lipid digestion, show great potential for curcumin cell entry.
机译：姜黄素和酸性槐糖脂在水溶液中的共超声处理显示出通过减小尺寸和包封可显着提高姜黄素的生物利用度。基于光学吸收，光致发光，动态光散射（DLS），ζ电位，FE-SEM，TEM，红外光谱和X射线衍射测量，研究和讨论了两者之间的相互作用。姜黄素与槐糖脂复合物的形成可显着增强姜黄素对乳腺癌细胞MCF-7和MDA-MB-231的细胞毒性作用。姜黄素与其SL（A）复合物的相对细胞毒性更多是由于葡萄糖部分的存在。结果进一步表明，基于脂溶性的脂溶性制剂在脂质消化后可溶解并纳米囊化姜黄素，显示出姜黄素进入细胞的巨大潜力。

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