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首页> 外文期刊>RSC Advances >Dual enzyme responsive and targeted nanocapsules for intracellular delivery of anticancer agents
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Dual enzyme responsive and targeted nanocapsules for intracellular delivery of anticancer agents

机译：双酶反应性和靶向纳米胶囊用于细胞内抗癌药的递送

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We report the fabrication of dual enzyme responsive hollow nanocapsules which can be targeted to deliver anticancer agents specifically inside cancer cells. The enzyme responsive elements, integrated in the nanocapsule walls, undergo degradation in the presence of either trypsin or hyaluronidase leading to the release of encapsulated drug molecules. These nanocapsules, which were crosslinked and functionalised with folic acid, showed minimal drug leakage when kept in pH 7.4 PBS buffer, but released the drug molecules at a rapid rate in the presence of either one of the triggering enzymes. Studies on cellular interactions of these nanocapsules revealed that doxorubicin loaded nanocapsules were taken up by cervical cancer cells via folic acid receptor medicated endocytosis. Interestingly the nanocapsules were able to disintegrate inside the cancer cells and release doxorubicin which then migrated into the nucleus to induce cell death. This study indicates that these nanocapsules fabricated from biopolymers can serve as an excellent platform for targeted intracellular drug delivery to cancer cells.
机译：我们报告了双重酶响应空心纳米胶囊的制造，其可以有针对性地专门在癌细胞内传递抗癌剂。整合在纳米胶囊壁中的酶反应元件在胰蛋白酶或透明质酸酶存在下发生降解，从而导致包封的药物分子释放。这些被叶酸交联和功能化的纳米胶囊，当保存在pH 7.4 PBS缓冲液中时，显示出最小的药物泄漏，但是在任何一种触发酶的存在下，药物分子均以快速速率释放。这些纳米胶囊的细胞相互作用研究表明，载有阿霉素的纳米胶囊被子宫颈癌细胞通过叶酸受体介导的内吞作用吸收。有趣的是，纳米胶囊能够在癌细胞内分解并释放阿霉素，然后阿霉素迁移到细胞核中诱导细胞死亡。这项研究表明，这些由生物聚合物制成的纳米胶囊可作为将细胞内靶向药物递送至癌细胞的绝佳平台。

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