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首页> 外文期刊>RSC Advances >Simultaneous spectrophotometric determination of ceftazidime and sulbactam using multivariate calibration methods
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Simultaneous spectrophotometric determination of ceftazidime and sulbactam using multivariate calibration methods

机译：多元校正法同时分光光度法测定头孢他啶和舒巴坦

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摘要

The simultaneous spectrophotometric determination of ceftazidime (CTZ) and sulbactam (SBT) in the presence of the overlapping spectra were accomplished with the partial least squares (PLS) and genetic algorithm-partial least squares (GA-PLS) approaches. In this study, the calibration set was based on the absorption spectra in the range of 230-350 nm for 25 different mixtures of CTZ and SBT. The calibration curve was linear over the concentration range of 2-30 and 4-46 mg mL(-1) for CTZ and SBT, respectively. These two methods were tested by analyzing the synthetic mixtures of the CTZ and SBT and they were applied to real samples containing a commercial pharmaceutical preparation of the subject drugs. Good results were obtained by the two methods. However, the accuracy of the GA-PLS method was better than that of the PLS method.
机译：使用偏最小二乘法（PLS）和遗传算法-偏最小二乘法（GA-PLS）方法同时测定了头孢他啶（CTZ）和舒巴坦（SBT）的同时分光光度法。在这项研究中，校准集基于25种CTZ和SBT混合物在230-350 nm范围内的吸收光谱。对于CTZ和SBT，校准曲线分别在2-30和4-46 mg mL（-1）的浓度范围内是线性的。通过分析CTZ和SBT的合成混合物测试了这两种方法，并将它们应用于包含主题药物的商业药物制剂的实际样品中。两种方法均取得了良好的效果。但是，GA-PLS方法的准确性优于PLS方法。

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