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首页> 外文期刊>RSC Advances >A FITC-doped silica coated gold nanocomposite for both in vivo X-ray CT and fluorescence dual modal imaging
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A FITC-doped silica coated gold nanocomposite for both in vivo X-ray CT and fluorescence dual modal imaging

机译：FITC掺杂的二氧化硅涂层的金纳米复合材料，用于体内X射线CT和荧光双模态成像

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摘要

Dual-modal imaging contrast agents with unique X-ray computed tomography (CT) and optical imaging capabilities have attracted much attention in recent years. Herein, the new silica hybrid nanocomposites containing Au nanoparticles and FITC dyes (FITC-Au@SiO2) were investigated as this kind of contrast agent. TEM characterization showed that the as-synthesized FITC-Au@SiO2 nanoprobes were uniform in morphology with the average size of 90 nm. After the PEGylation, the obtained FITC-Au@SiO2@PEG exhibited good dispersion stability under different conditions. The MTT assay suggested that FITCAu@SiO2@PEG didn't show appreciable toxicity toward KB cells even at high concentration of up to 1000 mg mL(-1). In addition, it was found that FITC-Au@SiO2@PEG could cross the cell membrane and enter into the cytoplasm during the incubation with cells. In vivo dual modal optical/CT imaging of C57BL/6J mice uncovered that within 2 h post-injection FITC-Au@SiO2@PEG nanoprobes preferred to accumulate in the liver and were gradually cleared through the enterohepatic circulation system, which could bring novel opportunities to the next generation of dual-modality contrast agents.
机译：近年来，具有独特的X射线计算机断层扫描（CT）和光学成像功能的双峰成像造影剂备受关注。在这里，研究了新型的含金纳米粒子和FITC染料的二氧化硅杂化纳米复合材料（FITC-Au @ SiO2）作为这种造影剂。 TEM表征表明，合成后的FITC-Au @ SiO2纳米探针形态均匀，平均大小为90 nm。聚乙二醇化后，得到的FITC-Au @ SiO2 @ PEG在不同条件下均表现出良好的分散稳定性。 MTT分析表明，即使在高达1000 mg mL（-1）的高浓度下，FITCAu @ SiO2 @ PEG也不显示对KB细胞的明显毒性。另外，发现FITC-Au @ SiO2 @ PEG在与细胞孵育期间可以穿过细胞膜并进入细胞质。 C57BL / 6J小鼠的体内双模态光学/ CT成像发现，注射后2小时内，FITC-Au @ SiO2 @ PEG纳米探针倾向于在肝脏中积累，并通过肠肝循环系统逐渐清除，这可能带来新的机会下一代双模造影剂。

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