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首页> 外文期刊>RSC Advances >Fluorescent small Au nanodots prepared from large Ag nanoparticles for targeting and imaging cancer cells
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Fluorescent small Au nanodots prepared from large Ag nanoparticles for targeting and imaging cancer cells

机译：由大型Ag纳米粒子制备的用于靶向和成像癌细胞的荧光金Au纳米点

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摘要

Developing an approach for targeting and detecting cancer cells has long been a challenge. Herein, the folic acid (FA) conjugated gold nanodots (Au NDs) are designed for specifically targeting and imaging folate receptor (FR) positive cancerous cells. Fluorescent small Au NDs were synthesized using stable Ag NPs with size above 50 nm and GSH as capping agent. This method solves the problems of low stability and difficulty in purification of small Ag NDs as templates. The resulting Au NDs display pink fluorescence with an emission peak at 582 nm. As-prepared Au NDs provide tunable fluorescence with a significant red shift (similar to 60 nm) with increase in the amount of GSH. In addition, GSH acts as a protecting layer, which could provide original functional groups (thiol, carboxyl and amine) and make Au NDs exhibit outstanding properties such as dispersibility in water, high stability, good biocompatibility and surface bioactivity. These characteristics make them suitable for further conjugation with FA. FA-conjugated Au NDs show the specific target HeLa cancer cells compared with 293T normal cells. These properties provide Au NDs with potential applications in distinguishing FR-positive cancer cells from normal cells.
机译：长期以来，开发一种靶向和检测癌细胞的方法一直是一个挑战。在本文中，叶酸（FA）共轭金纳米点（Au NDs）设计用于特异性靶向和成像叶酸受体（FR）阳性癌细胞。使用尺寸大于50 nm的稳定Ag NP和GSH作为封端剂合成了荧光小的Au ND。该方法解决了稳定性低和难以纯化小的Ag NDs作为模板的问题。所得的Au NDs显示出粉红色荧光，其发射峰在582nm处。制备的Au NDs随GSH量的增加而提供可调谐的荧光，具有明显的红移（类似于60 nm）。此外，GSH充当保护层，可以提供原始的官能团（硫醇，羧基和胺基），并使Au NDs表现出出色的性能，例如在水中的分散性，高稳定性，良好的生物相容性和表面生物活性。这些特性使其适合与FA进一步结合。与293T正常细胞相比，与FA结合的Au NDs显示出特定的靶标HeLa癌细胞。这些特性为Au NDs在区分FR阳性癌细胞和正常细胞方面提供了潜在的应用。

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