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首页> 外文期刊>RSC Advances >Synthesis of a novel pH responsive phyllosilicate loaded polymeric hydrogel based on poly(acrylic acid-co-N-vinylpyrrolidone) and polyethylene glycol for drug delivery: modelling and kinetics study for the sustained release of an antibiotic drug
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Synthesis of a novel pH responsive phyllosilicate loaded polymeric hydrogel based on poly(acrylic acid-co-N-vinylpyrrolidone) and polyethylene glycol for drug delivery: modelling and kinetics study for the sustained release of an antibiotic drug

机译：基于聚（丙烯酸-co-N-乙烯基吡咯烷酮）和聚乙二醇的新型pH响应的负载页硅酸盐的聚合物水凝胶的合成，用于药物递送：持续释放抗生素药物的模型和动力学研究

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In this study, we developed a novel pH-sensitive composite interpenetrating polymeric network (IPN) hydrogel based on polyethylene glycol (PEG) and poly(acrylic acid-co-N-vinylpyrrolidone) crosslinked with N, N-methylenebisacrylamide (MBA). This composite was used for the controlled release (CR) of cefadroxil, an antibiotic drug. A systematic method via in situ polymerization in sodium aluminosilicate dispersion media was also performed to achieve a much higher degree of swelling behaviour followed by sufficient gel strength in the simulated pH atmosphere. The resulting hydrogel imprinted was characterized by Fourier transform infrared spectroscopy (FTIR) to confirm the copolymer formation and cross linking reaction, and scanning electron microscopy (SEM) to understand the surface morphology. Differential thermal analysis thermogravimetric analysis (DTA-TGA) and X-ray diffraction (XRD) were also performed to investigate the deviations from crystallinity and swelling experiments. The in vitro release of the drug loaded hydrogel performed in the acidic and basic media affected the drug release characteristics. The release data was analysed using an empirical equation to understand the transport of a drug-containing solution through the polymeric matrices. The wt% of PEG, MBA, initiator, total monomer concentration, pH of the medium was found to strongly influence the drug release behaviour of the gels. The impression of drug loading on the encapsulation efficiency was also investigated. The release rate of the drug was much faster at pH 7.8 than at pH 1.7. The modelling and kinetics of sustained release of antibiotic is reported.
机译：在这项研究中，我们开发了一种新型的pH敏感型复合互穿聚合物网络（IPN）水凝胶，该凝胶基于聚乙二醇（PEG）和与N，N-亚甲基双丙烯酰胺（MBA）交联的聚（丙烯酸-co-N-乙烯基吡咯烷酮）。该复合物用于头孢曲氨酯（一种抗生素药物）的控释（CR）。还进行了在铝硅酸钠分散介质中通过原位聚合的系统方法，以实现更高程度的溶胀行为，随后在模拟pH气氛中获得足够的凝胶强度。通过傅立叶变换红外光谱（FTIR）对所得水印进行表征，以确认共聚物的形成和交联反应，并通过扫描电子显微镜（SEM）来了解表面形态。还进行了差示热分析，热重分析（DTA-TGA）和X射线衍射（XRD），以研究结晶度和溶胀实验的偏差。在酸性和碱性介质中进行的载有药物的水凝胶的体外释放影响了药物的释放特性。使用经验方程分析释放数据，以了解含药溶液通过聚合物基质的传输。发现PEG，MBA，引发剂，总单体浓度，介质的pH的重量％强烈影响凝胶的药物释放行为。还研究了载药量对封装效率的印象。在pH 7.8时，药物的释放速率比在pH 1.7时快得多。报道了持续释放抗生素的模型和动力学。

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