• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor
【24h】

NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor

机译：基于核磁共振的代谢组学揭示了姜黄素介导携带CT26肿瘤的恶病质小鼠的独特途径

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: cachexia is common in cancer patients, with profound metabolic abnormalities in response to malignant growth of cancer and progressive catabolism of host. Previous studies showed pharmacodynamics efficacy of curcumin in the prevention and treatment of cancer cachexia. However, the metabolic regulation effect is still unknown. Methods: we employed a proton NMR-metabonomics method to investigate the metabolic features of cancer cachexia and the contribution of curcumin to serum metabolites in a mouse model bearing CT26 tumor. Results: curcumin treatment (200 mg per kg per day) resulted in 13.9% less body weight loss and conserved mass of epididymal fat, muscle gastrocnemius and muscle tibialis anterior 91.4%, 11.5%, and 13.7% respectively in cancer cachexia mice. Proton NMR-based metabolomics revealed the altered metabolic profile and found 25 sensitive metabolites associated with cancer cachexia. Moreover, curcumin treatment resulted in metabolic reprogramming including decrease of phenylalanine, alanine, carnosine, carnitine, taurine, S-sulfocysteine, citrate, malate, glucose, and increase of citrulline, valine, isoleucine, methionine, glycine, acetoacetate and lactate. The pathway analysis showed that the main metabolic regulation of curcumin involved the metabolism of valine, leucine and phenylanaline, and synthesis and degradation of ketone bodies. Conclusions: these altered metabolic pathways imply a highly specific metabolism regulation of curcumin and raise the possibility for its therapeutic effect on alleviating cachexia hypermetabolism.
机译：背景：恶病质在癌症患者中很常见，对癌症的恶性生长和宿主的进行性分解代谢有很强的代谢异常。先前的研究表明姜黄素在预防和治疗癌症恶病质中的药效学功效。然而，代谢调节作用仍然未知。方法：我们采用质子NMR代谢组学方法研究了癌症恶病质的代谢特征以及姜黄素对携带CT26肿瘤的小鼠模型中血清代谢产物的影响。结果：姜黄素治疗（每天每千克200 mg）可使癌症恶病质小鼠的体重减轻减少13.9％，附睾脂肪，腓肠肌和胫骨前肌的保留质量分别降低91.4％，11.5％和13.7％。基于质子NMR的代谢组学揭示了代谢特征的改变，并发现了与癌症恶病质相关的25种敏感代谢物。此外，姜黄素治疗导致代谢重编程，包括减少苯丙氨酸，丙氨酸，肌肽，肉碱，牛磺酸，硫代半胱氨酸，柠檬酸盐，苹果酸，葡萄糖，并增加瓜氨酸，缬氨酸，异亮氨酸，蛋氨酸，甘氨酸，乙酰乙酸和乳酸。信号通路分析表明，姜黄素的主要代谢调控机制涉及缬氨酸，亮氨酸和苯苯胺的代谢以及酮体的合成和降解。结论：这些改变的代谢途径暗示姜黄素具有高度特异性的代谢调节作用，并增加了其缓解恶病质过度代谢的治疗作用的可能性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号