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首页> 外文期刊>RSC Advances >Nanodispersions of monoglycerides of punicic acid: a potential nutrient precursor with higher oxidative stability and cytotoxicity
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Nanodispersions of monoglycerides of punicic acid: a potential nutrient precursor with higher oxidative stability and cytotoxicity

机译：石榴酸单甘油酯的纳米分散体：一种潜在的营养前体，具有较高的氧化稳定性和细胞毒性

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摘要

Punicic acid belongs to one of conjugated linolenic acids isomers (CLnAs) and contains many outstanding functions related to human health such as anti-carcinogenic, anti-diabetes, anti-hyperlipidemia, anti-obesity and anti-atherosclerotic properties; moreover, interest in the punicic acid is growing. Note that since punicic acid is extremely susceptible to oxidation, antioxidants were often added to increase its stability. However, sometimes such method resulted in the great decrease of its antitumor activity. In addition, punicic acid is quite insoluble in water and only a minor fraction of it can be absorbed. Therefore, the present study aims to identify a method, which can maintain the cytotoxicity when there is an increase in the oxidative stability and solubility of punicic acid. In brief, free punicic acid was modified with glycerol and the amphiphilic monoglycerides of punicic acid were obtained, which were further dispersed to nanodispersions. Oxidative stability, cytotoxicity to NIH3T3 cells and digestion in intestinal juice of such nanodispersions under different conditions were studied. It was found that such nanodispersions showed higher oxidative stability, higher solubility in water. Most importantly, its cytotoxicity to NIH3T3 cells was also as strong as that of free punicic acid. Furthermore, since it can be hydrolyzed by pancreatin in intestinal juice, the nanodispersions formed by monoglycerides of punicic acid can be used as nutrient precursor of free punicic acid.
机译：石榴酸属于共轭亚麻酸异构体（CLnAs）之一，具有许多与人体健康相关的出色功能，例如抗癌，抗糖尿病，抗高血脂，抗肥胖和抗动脉粥样硬化特性;此外，对石榴酸的兴趣正在增长。请注意，由于石榴酸极易氧化，因此通常添加抗氧化剂以增加其稳定性。但是，有时这种方法导致其抗肿瘤活性大大降低。此外，石榴酸非常不溶于水，仅其中一小部分可以被吸收。因此，本研究旨在确定一种方法，该方法可以在石榴酸的氧化稳定性和溶解度增加时保持细胞毒性。简而言之，用甘油对游离的石榴酸进行改性，获得了石榴酸的两亲性单甘油酯，将其进一步分散成纳米分散体。研究了这种纳米分散体在不同条件下的氧化稳定性，对NIH3T3细胞的细胞毒性以及在肠液中的消化。发现这种纳米分散体显示出更高的氧化稳定性，更高的在水中的溶解度。最重要的是，它对NIH3T3细胞的细胞毒性也与游离石榴酸一样强。此外，由于其可被胰液在肠液中水解，因此由石榴酸单甘油酯形成的纳米分散体可用作游离石榴酸的营养前体。

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