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首页> 外文期刊>RSC Advances >Crosslinked polyelectrolyte complex fiber membrane based on chitosan-sodium alginate by freeze-drying
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Crosslinked polyelectrolyte complex fiber membrane based on chitosan-sodium alginate by freeze-drying

机译：壳聚糖-海藻酸钠冷冻干燥交联聚电解质复合纤维膜

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摘要

Polyelectrolyte complex (PEC) membrane of cationic chitosan and anionic sodium alginate with fiber structure were prepared by freeze-drying method. Chitosan and sodium alginate were blended in different concentrations and frozen at different temperatures. Freeze-dried fiber membranes were extensively characterized for their inter-molecular interaction, the solution property, morphology and biocompatibility by using FTIR, XRD, zeta (zeta) potentials, SEM and cytotoxicity assay. The study of swelling property showed that PEC membrane with the fiber structure cross-linked with glutaraldehyde exhibited pH and ionic strength-dependent swelling in aqueous media, which might have a potential application in tissue engineering or drug controlled release. Furthermore, chitosan-sodium alginate samples showed better cell adhesion and proliferation than pure chitosan. The results indicated that two natural polyelectrolyte complex nanofibers were prepared by freeze-drying method and fitted for tissue engineering or as drug carriers.
机译：采用冷冻干燥法制备了阳离子型壳聚糖和阴离子型海藻酸钠的聚电解质复合膜。将壳聚糖和海藻酸钠以不同浓度混合并在不同温度下冷冻。通过FTIR，XRD，ζ（zeta）电势，SEM和细胞毒性测定，对冻干纤维膜的分子间相互作用，溶液性质，形态和生物相容性进行了广泛表征。溶胀性能的研究表明，纤维结构与戊二醛交联的PEC膜在水性介质中表现出pH和离子强度依赖性溶胀，这可能在组织工程或药物控释中具有潜在的应用。此外，壳聚糖-海藻酸钠样品显示出比纯壳聚糖更好的细胞粘附和增殖。结果表明，采用冷冻干燥法制备了两种天然的聚电解质复合纳米纤维，可用于组织工程或作为药物载体。

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