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首页> 外文期刊>RSC Advances >Functional hybrids of layered double hydroxides with hemin: synergistic effect for peroxynitrite-scavenging activity
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Functional hybrids of layered double hydroxides with hemin: synergistic effect for peroxynitrite-scavenging activity

机译：具有血红素的层状双氢氧化物的功能杂化物：清除过氧亚硝酸盐活性的协同作用

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摘要

Hemin has been successfully modified onto the surface of CuAl layered double hydroxide nanosheets by a simple coprecipitation process, which afforded a hemin modified CuAl layered double hydroxide (H-LDH) hybrid functional material that exhibited protective effects against the harmful ONOO-. The obtained products were characterized by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy and Fourier transform infrared spectroscopy, which showed that the samples had hexagonal symmetry structure with a mean lateral size of 1 mm, on the surface of which were adsorbed round particles with a diameter of about 300 nm. A detailed inhibition study on ONOO--mediated nitration reactions indicated that the interaction between hemin and LDHs results in a synergistic effect, which leads to an efficient reduction of ONOO- to nitrate. The present study suggests that the H-LDHs had an efficient ONOO- scavenging ability, and may well be a potent ONOO- scavenger for protection of the cellular defense activity against ONOO- involved diseases.
机译：通过简单的共沉淀过程，将血红素成功地修饰到了CuAl层状双氢氧化物纳米片的表面上，从而提供了一种血红素修饰的CuAl层状双氢氧化物（H-LDH）杂化功能材料，对有害的ONOO-具有保护作用。通过X射线粉末衍射，扫描电子显微镜，透射电子显微镜和傅里叶变换红外光谱对所得产物进行表征，结果表明样品具有六边形对称结构，平均横向尺寸为1mm，其表面被吸附。直径约300 nm的圆形颗粒。对ONOO介导的硝化反应的详细抑制研究表明，血红素和LDH之间的相互作用会产生协同效应，从而导致ONOO-有效还原为硝酸盐。本研究表明，H-LDH具有有效的ONOO清除能力，并且很可能是有效的ONOO清除剂，可保护细胞抵抗ONOO参与的疾病的防御活性。

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