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首页> 外文期刊>RSC Advances >Bioactivity of Satureja montana L. honey extracts and their profile screening
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Bioactivity of Satureja montana L. honey extracts and their profile screening

机译：蒙太奇蜂蜜提取物的生物活性及其概况筛选

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摘要

Exploitation of natural compounds, including those from the honeys, as therapeutic agents is still gaining importance, but problems may arise due to poor knowledge of molecular effects and correlation of these effects with doses. The aim of the study was to characterize the extracts from winter savory (Satureja montana L.) honey, evaluate their bioactivity depending on the variety of obtained extracts, concentrations of main compounds and their interrelationship depending on doses. For this purpose the honey samples were processed by ultrasonic solvent extraction (solvent pentane : diethyl ether 1 : 2 v/v) and the obtained extracts were characterized by gas chromatography and mass spectrometry. For the first time, antioxidative and antiproliferative effects accompanied by apoptosis induction and cell death of S. montana honey samples and their extracts on tumour cell lines were presented. Methyl syringate (MS) and syringaldehyde (SA) were identified as the major components of S. montana honey extracts with radical scavenging capacity (Trolox equivalent antioxidant capacity; TEAC) of 13.04 mmol TEAC per kg (MS) and 422.02 mmol TEAC per kg (SA), respectively. Tested extracts, MS and SA did not exhibit any genotoxic effects detectable by the alkaline comet assay but they, as well as S. montana honey samples, clearly pointed to a strong antiproliferative effect in vitro on the tumour cell lines growth in a concentration-dependent manner accompanied with apoptosis induction and cell death.
机译：开发天然化合物，包括蜂蜜中的天然化合物作为治疗剂仍然越来越重要，但是由于对分子效应的了解不足以及这些效应与剂量的相关性，可能会出现问题。这项研究的目的是表征冬香（Satureja montana L.）蜂蜜的提取物，根据所得提取物的种类，主要化合物的浓度以及剂量之间的相互关系评估其生物活性。为此，通过超声溶剂萃取（溶剂戊烷：乙醚1：2 v / v）对蜂蜜样品进行处理，并通过气相色谱和质谱法对所得提取物进行表征。首次提出了山茱S蜂蜜样品及其提取物在肿瘤细胞系上的抗氧化和抗增殖作用，伴随凋亡诱导和细胞死亡。丁香酸甲酯（MS）和丁香醛（SA）被确定为蒙大拿中的蜂蜜提取物的主要成分，其自由基清除能力（Trolox等效抗氧化剂能力; TEAC）为13.04 mmol TEAC / kg（MS）和422.02 mmol TEAC / kg（ SA）。经测试的提取物，MS和SA均未显示出通过碱彗星试验可检测到的任何遗传毒性作用，但它们以及蒙大拿州的S. montana蜂蜜样品清楚地表明，浓度依赖于体外对肿瘤细胞系的生长具有很强的抗增殖作用。伴有凋亡诱导和细胞死亡。

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