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Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels

机译：高效超声法可有效合成基于乙二醇的热敏纳米凝胶

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摘要

The employment of nanogels (NGs) for drug delivery purposes has experienced a huge increase during the last decades. Among the different NGs, those displaying stimuli-responsive properties are of special interest. In particular, NGs that are able to swell or shrink by the action of temperature are very promising materials for applications in the biomedical and biological fields. In this work we present the preparation of thermoresponsive ethylene glycol-based NGs employing a simple and reliable ultrasonication approach. By this means, the reaction times could be shortened and the NGs formation could be performed even at room temperature and in the presence of oxygen. The NGs have been characterized by different techniques and their cloud point could be tuned by changing the molar ratio between the monomers. Finally, the NGs were labelled with Rhodamine B and their cellular uptake and cytotoxicity have been analysed.
机译：在过去的几十年中，用于药物输送的纳米凝胶（NGs）的使用已大大增加。在不同的NG中，具有刺激响应特性的NG具有特别的意义。特别地，能够通过温度作用而膨胀或收缩的NG是用于生物医学和生物领域的非常有前途的材料。在这项工作中，我们介绍了使用简单可靠的超声方法制备热敏性乙二醇基NG的方法。通过这种方式，可以缩短反应时间并且即使在室温下和在氧气存在下也可以进行NGs的形成。 NG具有不同的技术特征，可以通过改变单体之间的摩尔比来调节其浊点。最后，用罗丹明B标记NG，并分析了它们的细胞摄取和细胞毒性。

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