A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

Chen Jianbin; Natte Kishore; Neumann Helfried; Wu Xiao-Feng

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A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

机译：由2-氨基苄胺和芳基溴化物方便地钯催化羰基合成喹唑啉

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A novel and practical strategy towards quinazoline scaffolds synthesis has been achieved. Through palladium-catalyzed carbonylative coupling of 2-aminobenzylamine with aryl bromides, the desired quinazolines were produced in moderate to good yields for the first time. The reactions followed an aminocarbonylation-condensation-oxidation sequence in a one-pot one-step manner. Preliminary investigation showed DMSO serves both as solvent and oxidant in this procedure.

机译：已经实现了新颖且实用的喹唑啉支架合成策略。通过2-氨基苄基胺与芳基溴化物的钯催化羰基化偶联，首次以中等至良好的收率生产了所需的喹唑啉。反应以一锅一步的方式遵循氨基羰基化-缩合-氧化顺序。初步研究表明，DMSO在此过程中既充当溶剂又充当氧化剂。

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《RSC Advances》 |2014年第99期|共4页
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Chen Jianbin; Natte Kishore; Neumann Helfried; Wu Xiao-Feng;
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正文语种 eng
中图分类化学;
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1. A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides [J] . Chen Jianbin, Natte Kishore, Neumann Helfried, RSC Advances . 2014,第99期

机译：由2-氨基苄胺和芳基溴化物方便地钯催化羰基合成喹唑啉
2. A General and Convenient Palladium-Catalyzed Carbonylative Sonogashira Coupling of Aryl Bromides [J] . Xiao-Feng Wu Dr. Helfried Neumann Prof. Dr. Matthias Beller Chemistry - A European Journal . 2010,第40期

机译：通用和方便的钯催化的芳基溴化物的羰基化Sonogashira偶联
3. Palladium-Catalyzed Carbonylative Coupling of Aryl Iodides with Alkyl Bromides: Efficient Synthesis of Alkyl Aryl Ketones [J] . Peng Jin-Bao, Chen Bo, Qi Xinxin, Advanced synthesis & catalysis . 2018,第21期

机译：钯催化芳基溴化物的羰基化偶联与烷基溴：烷基芳基酮的有效合成
4. Palladium-Catalyzed gamma -Selective Cross-Coupling of Potassium Allyltrifluoroborates with Aryl and 1-Alkenyl Bromides [C] . Yasunori Yamamoto, Shingo Takada, Norio Miyaura Symposium on Organometallic Chemistry . 2006

机译：钯催化的丙烷与芳基和1-链烯基溴硼硼酸钾的丙烷的交叉偶联
5. Synthesis of sterically-hindered 2,2-disubstituted ethyltrifluoroborate salts and their palladium-catalyzed cross-coupling with aryl and vinyl bromides. [D] . Guinn, Robert H. 2011

机译：位阻2,2-二取代的乙基三氟硼酸盐的合成及其钯与芳基和乙烯基溴的交叉偶联。
6. Carbonylative Cross-Coupling of ortho-Disubstituted Aryl Iodides. Convenient Synthesis of Sterically Hindered Aryl Ketones [O] . B. Michael O’Keefe, Nicholas Simmons, Stephen F. Martin -1

机译：邻二取代芳基碘化物的羰基交叉偶联。立体受阻芳基酮的便捷合成
7. Palladium-catalyzed carbonylative synthesis of N-cyanobenzamides from aryl iodides/bromides and cyanamide [O] . Mane Rajendra S., Nordeman Patrik, Odell Luke R., 2013

机译：芳基碘化物/溴化物和氰胺的钯催化羰基合成N-氰基苯甲酰胺

A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

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