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Graphene oxide incorporated collagen-fibrin biofilm as a wound dressing material

机译:氧化石墨烯掺入胶原纤维蛋白生物膜作为伤口护理材料

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摘要

Functionalized graphene oxide offers many advantages as a biomaterial in various biomedical applications. In the present study, graphene oxide (GO) was incorporated in the collagen-fibrin composite film (CFGO) and used as wound dressing material in both in vitro and in vivo studies. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using NIH 3T3 cells revealed that CFGO film is biocompatible. CFGO was also used as a wound dressing material on the experimental wounds of rats. Histopathological, biochemical and hematology studies have shown that the CFGO treated wounds healed faster than control and CF treated wounds. Based on the results, CFGO can be used as a wound dressing material in small and large animals.
机译:在各种生物医学应用中,功能化氧化石墨烯作为生物材料具有许多优势。在本研究中,氧化石墨烯(GO)被掺入胶原纤维蛋白复合膜(CFGO)中,并在体外和体内研究中用作伤口包扎材料。使用NIH 3T3细胞的3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物(MTT)分析显示CFGO膜具有生物相容性。 CFGO还用作大鼠实验伤口上的伤口包扎材料。组织病理学,生化和血液学研究表明,CFGO治疗的伤口愈合快于对照组和CF治疗的伤口。根据结果​​,CFGO可用作大小动物的伤口敷料。

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