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首页> 外文期刊>RSC Advances >Multifunctional iron oxide/silk-fibroin (Fe3O4-SF) composite microspheres for the delivery of cancer therapeutics
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Multifunctional iron oxide/silk-fibroin (Fe3O4-SF) composite microspheres for the delivery of cancer therapeutics

机译：多功能氧化铁/丝素蛋白（Fe3O4-SF）复合微球用于治疗癌症

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摘要

In this article, we report novel multifunctional iron oxide/silk-fibroin (Fe3O4-SF) microspheres synthesized by simple salting out process. These microspheres are used as the carriers of doxorubicin hydrochloride (a traditional anti-cancer drug), denoted as DOX-Fe3O4-SF. The results show that the drug loading capacity (LC) is 3.3% and the drug encapsulation efficiency (EE) could reach up to 76%. The DOX-loaded microspheres exhibit sustained and pH-sensitive release patterns. The total DOX release is measured to be about 60% at pH 5.5. More interestingly, RhB-labelled Fe3O4-SF microspheres exhibit a striking endocytosis, selectively accumulating in the cytoplasm compared to the free RhB. The endocytosis of DOX-Fe3O4-SF microspheres results in only similar to 10% survival ratio of HeLa cells after 48 h. Furthermore, because of the remarkable biocompatibility of SF, Fe3O4-SF microspheres show no cytotoxicity toward HeLa cells compared to DOX-Fe3O4-SF. The results clearly indicate that Fe3O4-SF microspheres hold significant potential for drug loading and delivery into cancer cells to induce cell death.
机译：在本文中，我们报告了通过简单的盐析过程合成的新型多功能氧化铁/丝素蛋白（Fe3O4-SF）微球。这些微球被用作盐酸阿霉素（一种传统的抗癌药物）的载体，表示为DOX-Fe3O4-SF。结果表明，载药量（LC）为3.3％，包封率（EE）可达76％。装有DOX的微球呈现出持续且对pH敏感的释放方式。在pH 5.5下测得的总DOX释放量约为60％。更有趣的是，RhB标记的Fe3O4-SF微球表现出惊人的内吞作用，与游离RhB相比，选择性地积累在细胞质中。 DOX-Fe3O4-SF微球的内吞作用导致48小时后HeLa细胞的存活率仅接近10％。此外，由于SF具有出色的生物相容性，与DOX-Fe3O4-SF相比，Fe3O4-SF微球对HeLa细胞没有细胞毒性。结果清楚地表明，Fe3O4-SF微球具有显着的潜力，可将药物装载并输送到癌细胞中以诱导细胞死亡。

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