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Flow through ring resonator sensing platform

机译：流经环形谐振器感应平台

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This paper presents a novel sensing polymeric platform based on microring resonators with a direct microfluidic addressing scheme employing a flow-through approach. The fabrication of a hole placed in the centre of the ring allows precise analyte dispensing with an efficient transfer rate to the ring surface. The devices are exploited for biosensing experiments with bovine serum albumin (BSA) based solutions. The measured resonance peak shift shows a linear behaviour up to 200 nM. The sensor response time is measured by flowing 20 nM BSA solution at two different flow rates and in two different flow-through configurations. A reduction of more than one order of magnitude of the sensor response time, as compared with the standard flow-over approach, is obtained with the proposed flow-through approach thanks to improved transport kinetics of the analyte. The proposed device architecture, in its intrinsic simplicity, gives numerous advantages related to time responses and multiplexing of different analytes, selectively addressed to the ring resonators, for label-free biosensing.
机译：本文提出了一种基于微环谐振器的新型传感聚合物平台，该平台具有采用流通方式的直接微流体寻址方案。放置在环中央的孔的制造允许精确的分析物分配以及向环表面的有效转移速率。该设备可用于基于牛血清白蛋白（BSA）的溶液的生物传感实验。测得的共振峰位移显示出高达200 nM的线性行为。传感器响应时间是通过使20 nM BSA溶液在两种不同的流速和两种不同的流通配置下流动来测量的。与提议的流通方法相比，与标准流通方法相比，传感器响应时间减少了一个数量级以上，这是由于分析物的传输动力学得到了改善。所提出的设备体系结构以其固有的简单性，提供了与时间响应和不同分析物的多路复用相关的众多优势，这些优点是有选择地针对环形共振器的，从而实现了无标记生物传感。

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